Effects of Autoantibodies on Osteoclasts

Sokolova M, Steffen U (2021)


Publication Type: Journal article, Review article

Publication year: 2021

Journal

DOI: 10.1055/a-1592-1305

Abstract

The balance between bone forming osteoblasts and bone resorbing osteoclasts can be disturbed in autoimmune diseases resulting in local and systemic bone loss. It was long time believed that autoantibodies only indirectly contribute to bone loss by fueling the overall inflammation. However, in the last decade, more and more evidence emerged that autoantibodies and immune complexes directly activate osteoclasts and pre-osteoclasts by binding to Fc gamma receptors (Fc gamma Rs) on the (pre)osteoclast cell surface. This pro-osteoclastogenic effect seems to be dependent on the absence of sialic acid in the IgG Fc glycan, which is a typical feature of many autoantibodies. Clinical studies revealed the importance of autoantibody-mediated bone loss mainly in rheumatoid arthritis, but also in other diseases, such as celiac disease. In summary, the gained knowledge about autoantibody-mediated bone loss helps to better understand bone pathologies of autoimmune diseases. However, studies are still relatively limited and more research is needed to fully understand the impact of autoantibodies on bone and to develop future therapeutic strategies.

Authors with CRIS profile

How to cite

APA:

Sokolova, M., & Steffen, U. (2021). Effects of Autoantibodies on Osteoclasts. Osteologie. https://dx.doi.org/10.1055/a-1592-1305

MLA:

Sokolova, Maria, and Ulrike Steffen. "Effects of Autoantibodies on Osteoclasts." Osteologie (2021).

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