Schwarz-Furlan S (2021)
Publication Type: Journal article
Publication year: 2021
DOI: 10.1007/s12285-021-00324-3
Background Salivary gland tumors are rare but display great morphological heterogeneity with more than 30 entities. Recently, the different tumors have not only been better characterized using conventional histochemical and immunohistochemical methods, but also by molecular means. Hence, so-called driver mutations which play a role in the development of novel molecularly targeted therapies could be identified. Objective The article aims to show morphological criteria and immunohistochemical characteristics of different tumor entities. Additionally, an overview of tumor-specific genetic aberrations of the most common salivary gland tumors is given. Materials and methods Samples from daily routine practice are presented with histochemical and immunohistochemical staining. To compile recent molecular findings in salivary gland tumors, a literature review was performed. Results and conclusion For histopathological diagnosis of differentiated salivary gland tumors, immunohistochemical staining of basal/myoepithelial and luminal/epithelial cells is essential to assess cellular architecture and attribute proliferative activity. Based on correct tumor typing, various molecular parameters can be investigated in order to verify the diagnosis of highly differentiated nonmetastatic tumors. In the case of less differentiated, metastatic cancers, molecular pathology permits identification of potential therapeutic targets. Comprehensive genome profiling should nowadays be applied to highly aggressive salivary gland cancers.
APA:
Schwarz-Furlan, S. (2021). Histology and molecular pathology of salivary gland tumors. Der MKG-Chirurg. https://dx.doi.org/10.1007/s12285-021-00324-3
MLA:
Schwarz-Furlan, Stephan. "Histology and molecular pathology of salivary gland tumors." Der MKG-Chirurg (2021).
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