Ophey A, Wolfsgruber S, Roeske S, Polcher A, Spottke A, Frolich L, Hull M, Jessen F, Kornhuber J, Maier W, Peters O, Ramirez A, Wiltfang J, Liepelt-Scarfone I, Becker S, Berg D, Schulz JB, Reetz K, Wojtala J, Kassubek J, Storch A, Balzer-Geldsetzer M, Hilker-Roggendorf R, Witt K, Mollenhauer B, Trenkwalder C, Wittchen HU, Riedel O, Dodel R, Wagner M, Kalbe E (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 13
Journal Issue: 1
DOI: 10.1002/dad2.12223
Introduction Large studies on cognitive profiles of patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD-MCI) compared to Parkinson's disease (PD-MCI) are rare. Methods Data from two multicenter cohort studies in AD and PD were merged using a unified base rate approach for the MCI diagnosis. Cognitive profiles were compared using scores derived from the Consortium to Establish a Registry for Alzheimer's Disease battery. Results Patients with AD-MCI showed lower standardized scores on all memory test scores and a language test. Patients with PD-MCI showed lower standardized scores in a set-shifting measure as an executive task. A cross-validated logistic regression with test scores as predictors was able to classify 72% of patients correctly to AD-MCI versus PD-MCI. Discussion The applied test battery successfully discriminated between AD-MCI and PD-MCI. Neuropsychological test batteries in clinical practice should always include a broad spectrum of cognitive domains to capture any cognitive changes.
APA:
Ophey, A., Wolfsgruber, S., Roeske, S., Polcher, A., Spottke, A., Frolich, L.,... Kalbe, E. (2021). Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments. Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, 13(1). https://doi.org/10.1002/dad2.12223
MLA:
Ophey, Anja, et al. "Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments." Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring 13.1 (2021).
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