Functional Fc Gamma Receptor Gene Polymorphisms and Long-Term Kidney Allograft Survival

Wahrmann M, Döhler B, Scherer S, Mayer KA, Haindl S, Haslacher H, Böhmig GA, Süsal C, Arnold M (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Frontiers in Immunology Frontiers Research Foundation / Frontiers Media

Book Volume: 12

Article Number: 724331

DOI: 10.3389/fimmu.2021.724331

Abstract

The functional Fc gamma receptor (FcγR) IIIA polymorphism FCGR3A-V/F158 was earlier suggested to determine the potential of donor-specific HLA antibodies to trigger microcirculation inflammation, a key lesion of antibody-mediated renal allograft rejection. Associations with long-term transplant outcomes, however, have not been evaluated to date. To clarify the impact of FCGR3A-V/F158 polymorphism on kidney transplant survival, we genotyped a cohort of 1,940 recipient/donor pairs. Analyzing 10-year death-censored allograft survival, we found no significant differences in relation to FCGR3A-V/F158. There was also no independent survival effect in a multivariable Cox model. Similarly, functional polymorphisms in two other activating FcγR, FCGR2A-H/R131 (FcγRIIA) and FCGR3B-NA1/NA2 (FcγRIIIB), were not associated with outcome. There were also no significant survival differences among patient subgroups at increased risk of rejection-related injury, such as pre-sensitized recipients (> 0% panel reactivity; n = 438) or recipients treated for rejection within the first year after transplantation (n = 229). Our study results suggest that the earlier shown association of FcγR polymorphism with microcirculation inflammation may not be strong enough to exert a meaningful effect on graft survival.

Authors with CRIS profile

Martin Arnold Department of Medicine 2 – Cardiology and Angiology

Involved external institutions

Medizinische Universität Wien AT Austria (AT) Universitätsklinikum Heidelberg DE Germany (DE)

How to cite

APA:

Wahrmann, M., Döhler, B., Scherer, S., Mayer, K.A., Haindl, S., Haslacher, H.,... Arnold, M. (2021). Functional Fc Gamma Receptor Gene Polymorphisms and Long-Term Kidney Allograft Survival. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.724331

MLA:

Wahrmann, Markus, et al. "Functional Fc Gamma Receptor Gene Polymorphisms and Long-Term Kidney Allograft Survival." Frontiers in Immunology 12 (2021).

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