Intrahepatic Cholestasis of Pregnancy

Jurk SM, Kremer A, Schleussner E (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Geburtshilfe und Frauenheilkunde Georg Thieme Verlag

Book Volume: 81

Pages Range: 940-947

Journal Issue: 8

DOI: 10.1055/a-1522-5178

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is a rare but potentially serious complication of pregnancy, the main symptom of which is intense pruritus with elevated serum levels of bile acids. The elevated serum bile acid concentration is regarded as a predictor for poor perinatal outcome including intrauterine death. Ursodeoxycholic acid (UDCA) has become established as the treatment of choice in clinical management to achieve a significant improvement in symptoms and reduce the cholestasis. Pregnant women with severe intrahepatic cholestasis should always be managed in a perinatal centre with close interdisciplinary monitoring and treatment involving perinatologists and hepatologists to minimise the markedly increased perinatal morbidity and mortality as well as maternal symptoms.

Authors with CRIS profile

Andreas Kremer Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology

Involved external institutions

Universitätsklinikum Jena DE Germany (DE)

How to cite

APA:

Jurk, S.M., Kremer, A., & Schleussner, E. (2021). Intrahepatic Cholestasis of Pregnancy. Geburtshilfe und Frauenheilkunde, 81(8), 940-947. https://doi.org/10.1055/a-1522-5178

MLA:

Jurk, Stanislaw M., Andreas Kremer, and Ekkehard Schleussner. "Intrahepatic Cholestasis of Pregnancy." Geburtshilfe und Frauenheilkunde 81.8 (2021): 940-947.

BibTeX: Download