Management of Intrahepatic Cholestasis of Pregnancy: Recommendations of the Working Group on Obstetrics and Prenatal Medicine - Section on Maternal Disorders
Hagenbeck C, Hamza A, Kehl S, Maul H, Lammert F, Keitel V, Hutten MC, Pecks U (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 81
Pages Range: 922-939
Journal Issue: 8
DOI: 10.1055/a-1386-3912
Abstract
Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease specific to pregnancy. The cardinal symptom of pruritus and a concomitant elevated level of bile acids in the serum and/or alanine aminotransferase (ALT) are suggestive for the diagnosis. Overall, the maternal prognosis is good. The fetal outcome depends on the bile acid level. ICP is associated with increased risks for adverse perinatal outcomes, including preterm delivery, meconium-stained amniotic fluid, and stillbirth. Acute fetal asphyxia and not chronic uteroplacental dysfunction leads to stillbirth. Therefore, predictive fetal monitoring is not possible. While medication with ursodeoxycholic acid (UDCA) improves pruritus, it has not been shown to affect fetal outcome. The indication for induction of labour depends on bile acid levels and gestational age. There is a high risk of recurrence in subsequent pregnancies.
Authors with CRIS profile
Involved external institutions
Universitätsklinikum Düsseldorf
Germany (DE)
Universitätsklinikum des Saarlandes (UKS)
Germany (DE)
Asklepios Kliniken
Germany (DE)
Maastricht University
Netherlands (NL)
Universitätsklinikum Schleswig-Holstein (UKSH)
Germany (DE)
Germany (DE)
Universitätsklinikum des Saarlandes (UKS)
Germany (DE)
Asklepios Kliniken
Germany (DE)
Maastricht University
Netherlands (NL)
Universitätsklinikum Schleswig-Holstein (UKSH)
Germany (DE)
How to cite
APA:
Hagenbeck, C., Hamza, A., Kehl, S., Maul, H., Lammert, F., Keitel, V.,... Pecks, U. (2021). Management of Intrahepatic Cholestasis of Pregnancy: Recommendations of the Working Group on Obstetrics and Prenatal Medicine - Section on Maternal Disorders. Geburtshilfe und Frauenheilkunde, 81(8), 922-939. https://doi.org/10.1055/a-1386-3912
MLA:
Hagenbeck, Carsten, et al. "Management of Intrahepatic Cholestasis of Pregnancy: Recommendations of the Working Group on Obstetrics and Prenatal Medicine - Section on Maternal Disorders." Geburtshilfe und Frauenheilkunde 81.8 (2021): 922-939.
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