Cellular identity through the lens of direct lineage reprogramming

Falk S, Han D, Karow M (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Current Opinion in Genetics & Development Elsevier

Book Volume: 70

Pages Range: 97-103

DOI: 10.1016/j.gde.2021.06.015

Abstract

Direct lineage reprogramming challenges our traditional view on basic aspects of cellular identity, and in particular on processes crucial for identity acquisition. This is partly because in direct lineage reprogramming but not during natural differentiation processes changing cellular identity can occur in the absence of mitosis. Only recently, technologies emerged to deconstruct the cellular and molecular processes governing the transitory states a cell passes through on the journey from its original identity to the new target cell fate. Here we discuss arising concepts on the nature of these transitory states and the challenges and decisions cells must conquer to reach their new cellular identity.

Authors with CRIS profile

Sven Falk Lehrstuhl für Biochemie und Pathobiochemie Dandan Han Professur für Biochemie und Molekulare Neurowissenschaften Marisa Karow-Falk Professur für Biochemie und Molekulare Neurowissenschaften

How to cite

APA:

Falk, S., Han, D., & Karow, M. (2021). Cellular identity through the lens of direct lineage reprogramming. Current Opinion in Genetics & Development, 70, 97-103. https://doi.org/10.1016/j.gde.2021.06.015

MLA:

Falk, Sven, Dandan Han, and Marisa Karow. "Cellular identity through the lens of direct lineage reprogramming." Current Opinion in Genetics & Development 70 (2021): 97-103.

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