Prion protein codon 129 polymorphism and risk of Alzheimer disease

(2004)

Publication Type: Journal article

Publication year: 2004

Journal

Neurology American Academy of Neurology (AAN)

Book Volume: 63

Pages Range: 364-366

Journal Issue: 2

DOI: 10.1212/01.WNL.0000130198.72589.69

Abstract

The authors investigated the PRNP Met¹²⁹Val polymorphism in 1,393 subjects including 482 patients with Alzheimer disease (AD) and two independent control groups. In patients, PRNP Met homozygosity conferred increasing risk with decreasing age at onset (onset: 61 to 70 years, n = 151, p = 0.02, odds ratio [OR] = 1.72, 95% CI = 1.2 to 2.53; onset: ≤60 years, n = 138, p = 0.013, OR = 1.92, 95% CI = 1.31 to 2.87), whereas no association was obtained in patients with onset at older than 70 years. The results suggest involvement of the prion protein in the pathogenesis of early-onset AD.