Schmohl J, Möbius S, Günther T, Pepeldjyika E, Seidel CL, Sutanto W, Schuster F, Kraemer D, Salih HR, Hartmann A, Tischer J, Ries C, Schmetzer H (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 41
Pages Range: 3891-3898
Journal Issue: 8
DOI: 10.21873/anticanres.15184
Background/Aim: Matrix metalloproteinases (MMPs) degrade extracellular matrix and process regulatory proteins. Recently, a membrane-bound 82kDa variant of proMMP-9 identified on myeloid blasts was shown to be associated with prognosis. Patients and Methods: To investigate the role of 82kDa proMMP-9 with acute lymphoblastic leukemia (ALL) and chronic lymphoid leukemia (CLL), we performed flow-cytometry analysis of expression on ALL blasts (n=18) and CLL lymphocytes (n=21) from blood and correlated data with clinical parameters. Results: In ALL, mature B-linear blasts expressed higher levels of 82kDa proMMP-9 compared to T-linear blasts. Elevated levels of 82kDa proMMP-9 were found in elderly patients and at patients with relapse. No correlation was observed on blood cells and extramedullary disease. In CLL, the 82kDa proMMP-9 expression did not correlate with any of the clinical parameters. Conclusion: Our findings suggest that higher levels of 82kDa proMMP-9 expression on blast cells may correlate with a more unfavorable ALL-subtype. Further studies are required to clarify the prognostic role of the 82kDa pro-MMP-9 expression.
APA:
Schmohl, J., Möbius, S., Günther, T., Pepeldjyika, E., Seidel, C.L., Sutanto, W.,... Schmetzer, H. (2021). Expression of surface-associated 82 kda prommp-9 in lymphatic leukemia blast cells differentially correlates with prognosis. Anticancer Research, 41(8), 3891-3898. https://doi.org/10.21873/anticanres.15184
MLA:
Schmohl, Jörg, et al. "Expression of surface-associated 82 kda prommp-9 in lymphatic leukemia blast cells differentially correlates with prognosis." Anticancer Research 41.8 (2021): 3891-3898.
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