Hamilton ST, Hahn F, Sonntag E, Marschall M, Rawlinson WD (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 112
Pages Range: 62-65
DOI: 10.1016/j.placenta.2021.06.013
Human cytomegalovirus congenital infection is the leading non-genetic cause of fetal malformation in developed countries. There are currently no safe antivirals for use during pregnancy. Placental trophoblast cells specifically secrete exosomes containing miRNA from the chromosome 19 miRNA cluster (C19MC) which confer viral resistance to recipient cells. We show the highly expressed C19MC miRNA miR-517a-3p inhibits HCMV replication and viral protein expression in both fibroblast and trophoblast cell cultures (71.6% and 50.4% inhibition of HCMV DNA at 7 days post infection respectively; p < 0.05). This naturally occurring molecule has potential for opening-up antiviral therapeutic strategies for pregnancy.
APA:
Hamilton, S.T., Hahn, F., Sonntag, E., Marschall, M., & Rawlinson, W.D. (2021). A placental specific miRNA miR-517a-3p exerts anti-human cytomegalovirus activity. Placenta, 112, 62-65. https://doi.org/10.1016/j.placenta.2021.06.013
MLA:
Hamilton, Stuart T., et al. "A placental specific miRNA miR-517a-3p exerts anti-human cytomegalovirus activity." Placenta 112 (2021): 62-65.
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