Analysis of over 10,000 cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome

White KL, Vierkant RA, Fogarty ZC, Charbonneau B, Block MS, Pharoah PDP, Chenevix-Trench G, Rossing MA, Cramer DW, Pearce CL, Schildkraut JM, Menon U, Kjaer SK, Levine DA, Gronwald J, Culver HA, Whittemore AS, Karlan BY, Lambrechts D, Wentzensen N, Kupryjanczyk J, Chang-Claude J, Bandera EV, Hogdall E, Heitz F, Kaye SB, Fasching P, Campbell I, Goodman MT, Pejovic T, Bean Y, Lurie G, Eccles D, Hein A, Beckmann M, Ekici AB, Paul J, Brown R, Flanagan JM, Harter P, Du Bois A, Schwaab I, Hogdall CK, Lundvall L, Olson SH, Orlow I, Paddock LE, Rudolph A, Eilber U, Dansonka-Mieszkowska A, Rzepecka IK, Ziolkowska-Seta I, Brinton L, Yang H, Garcia-Closas M, Despierre E, Lambrechts S, Vergote I, Walsh C, Lester J, Sieh W, Mcguire V, Rothstein JH, Ziogas A, Lubinski J, Cybulski C, Menkiszak J, Jensen A, Gayther SA, Ramus SJ, Gentry-Maharaj A, Berchuck A, Wu AH, Pike MC, Van Denberg D, Terry KL, Vitonis AF, Doherty JA, Johnatty SE, Defazio A, Song H, Tyrer J, Sellers TA, Phelan CM, Kalli KR, Cunningham JM, Fridley BL, Goode EL (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Book Volume: 22

Pages Range: 987-992

Journal Issue: 5

DOI: 10.1158/1055-9965.EPI-13-0028

Abstract

Background: Ovarian cancer is a leading cause of cancer-related death among women. In an effort to understand contributors to disease outcome,weevaluated single-nucleotide polymorphisms (SNP) previously associated with ovarian cancer recurrence or survival, specifically in angiogenesis, inflammation, mitosis, and drug disposition genes. Methods: Twenty-seven SNPs in VHL, HGF, IL18, PRKACB, ABCB1, CYP2C8, ERCC2, and ERCC1 previously associated with ovarian cancer outcome were genotyped in 10,084 invasive cases from 28 studies from the Ovarian Cancer Association Consortium with over 37,000-observed person-years and 4,478 deaths. Cox proportional hazards models were used to examine the association between candidate SNPs and ovarian cancer recurrence or survival with and without adjustment for key covariates. Results: We observed no association between genotype and ovarian cancer recurrence or survival for any of the SNPs examined. Conclusions: These results refute prior associations between these SNPs and ovarian cancer outcome and underscore the importance of maximally powered genetic association studies. Impact: These variants should not be used in prognostic models. Alternate approaches to uncovering inherited prognostic factors, if they exist, are needed. Cancer Epidemiol Biomarkers Prev; 22(5); 987-92. © 2013 American Association for Cancer Research.

Authors with CRIS profile

Involved external institutions

Mayo Clinic United States (USA) (US) University of Cambridge United Kingdom (GB) Oregon Health and Science University (OSHU) United States (USA) (US) University College London (UCL) United Kingdom (GB) University of Southern California (USC) United States (USA) (US) University of Kansas (KU) United States (USA) (US) Peter MacCallum Cancer Centre Australia (AU) National Cancer Institute (NCI) United States (USA) (US) Memorial Sloan Kettering Cancer Center United States (USA) (US) Dartmouth College United States (USA) (US) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) Cedars-Sinai Medical Center United States (USA) (US) Stanford University United States (USA) (US) Imperial College London / The Imperial College of Science, Technology and Medicine United Kingdom (GB) University of South Florida (USF) United States (USA) (US) University of California Irvine United States (USA) (US) Beatson West of Scotland Cancer Centre (BWSCC) United Kingdom (GB) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) The Institute of Cancer Research (ICR) United Kingdom (GB) Duke University United States (USA) (US) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) Rigshospitalet Denmark (DK) Danish Cancer Society Research Center Denmark (DK) HELIOS Kliniken Germany (DE) University of Medicine and Dentistry of New Jersey (UMDNJ) United States (USA) (US) University of Washington United States (USA) (US) University of Hawaii (U.H.) United States (USA) (US) Maria Skłodowska-Curie Institute of Oncology / Centrum Onkologii–Instytut im. Marii Skłodowskiej-Curie w Warszawie Poland (PL) Columbia University United States (USA) (US) Fred Hutchinson Cancer Research Center United States (USA) (US) Université Catholique de Louvain (UCL) Belgium (BE) QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research) Australia (AU) New Jersey, Department of Health United States (USA) (US) University of Southampton United Kingdom (GB) University of Sydney (USYD) Australia (AU)

How to cite

APA:

White, K.L., Vierkant, R.A., Fogarty, Z.C., Charbonneau, B., Block, M.S., Pharoah, P.D.P.,... Goode, E.L. (2013). Analysis of over 10,000 cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome. Cancer Epidemiology Biomarkers & Prevention, 22(5), 987-992. https://doi.org/10.1158/1055-9965.EPI-13-0028

MLA:

White, Kristin L., et al. "Analysis of over 10,000 cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome." Cancer Epidemiology Biomarkers & Prevention 22.5 (2013): 987-992.

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