Human sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine

Lampert A, Bennett DL, McDermott LA, Neureiter A, Eberhardt E, Winner B, Zenke M (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Neurobiology of Pain Elsevier

Book Volume: 8

Article Number: 100055

DOI: 10.1016/j.ynpai.2020.100055

Abstract

In this concise Mini-Review we will summarize ongoing developments of new techniques to study physiology and pathophysiology of the peripheral sensory nervous system in human stem cell derived models. We will focus on recent developments of reprogramming somatic cells into induced pluripotent stem cells, neural differentiation towards neuronal progenitors and human sensory neurons. We will sum up the high potential of this new technique for disease modelling of human neuropathies with a focus on genetic pain syndromes, such as gain- and loss-of-function mutations in voltage-gated sodium channels. The stem cell derived human sensory neurons are used for drug testing and we will summarize their usefulness for individualized treatment identification in patients with neuropathic pain. The review will give an outlook on potential application of this technique as companion diagnostics and for personalized medicine.

Authors with CRIS profile

Esther Eberhardt Department of Anaesthesiology Beate Winner Professur für Stammzell-Modelle seltener neuraler Erkrankungen

Additional Organisation(s)

Professur für Stammzell-Modelle seltener neuraler Erkrankungen Interdisziplinäres Zentrum für Klinische Forschung

Related research project(s)

Bavarian Research Association Interaction of Human Brain Cells (ForInter) March 1, 2019 - Dec. 31, 2023 IZKF-J66 (AN): ß subunits in human stem cell-derived nociceptors - adding pieces to the puzzle of pain Jan. 1, 2018 - Aug. 31, 2020

Involved external institutions

Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen DE Germany (DE) University of Oxford GB United Kingdom (GB)

How to cite

APA:

Lampert, A., Bennett, D.L., McDermott, L.A., Neureiter, A., Eberhardt, E., Winner, B., & Zenke, M. (2020). Human sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine. Neurobiology of Pain, 8. https://doi.org/10.1016/j.ynpai.2020.100055

MLA:

Lampert, Angelika, et al. "Human sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine." Neurobiology of Pain 8 (2020).

BibTeX: Download