Detraining Effects on Muscle Quality in Older Men with Osteosarcopenia. Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)

Ghasemikaram M, Engelke K, Kohl M, von Stengel S, Kemmler W (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Nutrients MDPI

Book Volume: 13

Journal Issue: 5

DOI: 10.3390/nu13051528

Abstract

The present study aimed to determine the effect of detraining on muscle quality (MQ) in older men with osteosarcopenia. Forty-three community-dwelling older men (78 ± 4 years) were randomly allocated to a consistently supervised high-intensity resistance exercise training (HIRT) group (n = 21) or a control group (CG, n = 22). The HIRT scheduled a periodized single set protocol twice weekly. After the intervention, the men were subjected to six months of detraining. Muscle quality (MQ), defined as maximum isokinetic hip/leg extensor strength per unit of mid-thigh intra-fascia volume, was determined by magnetic resonance imaging (MRI) or per unit of thigh muscle mass assessed by dual-energy X-ray absorptiometry (DXA). Intention-to-treat analysis with multiple imputations was applied. We observed significant exercise effects for MQ (p = 0.001). During detraining, the HIRT group lost about one-third of the intervention-induced gain and displayed significantly (p = 0.001) higher MQ reductions compared to the CG. Nevertheless, after training and detraining, the overall intervention effect on MQ remained significant (p ≤ 0.004). In summary, six months of absence from HIRT induce a significant deleterious effect on MQ in older osteosarcopenic men. We conclude that intermitted training programs with training breaks of six months and longer should be replaced by largely continuous exercise programs, at least when addressing MQ parameters.

Authors with CRIS profile

Mansour Ghasemikaram Lehrstuhl für Medizinische Physik und Mikrogewebetechnik Klaus Engelke Medizinische Fakultät Simon von Stengel Lehrstuhl für Medizinische Physik und Mikrogewebetechnik Wolfgang Kemmler Lehrstuhl für Medizinische Physik und Mikrogewebetechnik

Involved external institutions

Hochschule Furtwangen DE Germany (DE)

How to cite

APA:

Ghasemikaram, M., Engelke, K., Kohl, M., von Stengel, S., & Kemmler, W. (2021). Detraining Effects on Muscle Quality in Older Men with Osteosarcopenia. Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). Nutrients, 13(5). https://doi.org/10.3390/nu13051528

MLA:

Ghasemikaram, Mansour, et al. "Detraining Effects on Muscle Quality in Older Men with Osteosarcopenia. Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)." Nutrients 13.5 (2021).

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