Cord-blood-derived professional antigen-presenting cells: Functions and applications in current and prospective cell therapies

Cunningham S, Hackstein H (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

International Journal of Molecular Sciences MDPI

Book Volume: 22

Article Number: 5923

Journal Issue: 11

DOI: 10.3390/ijms22115923

Abstract

Human umbilical cord blood (UCB) represents a valuable source of hematopoietic stem cells, particularly for patients lacking a matching donor. UCB provides practical advantages, including a lower risk of graft-versus-host-disease and permissive human leukocyte antigen mismatching. These advantageous properties have so far been applied for stem cell, mesenchymal stromal cell, and chimeric antigen receptor T cell therapies. However, UCB-derived professional antigen-presenting cells are increasingly being utilized in the context of immune tolerance and regenerative therapy. Here, we review the cell-specific characteristics as well as recent advancements in UCB-based cell therapies focusing on dendritic cells, monocytes, B lymphocytes, innate lymphoid cells, and macrophages.

Authors with CRIS profile

Sarah Cunningham Department of Transfusion Medicine and Haemostaseology Holger Hackstein Professur für Transfusionsmedizin und Cell-Engineering

How to cite

APA:

Cunningham, S., & Hackstein, H. (2021). Cord-blood-derived professional antigen-presenting cells: Functions and applications in current and prospective cell therapies. International Journal of Molecular Sciences, 22(11). https://doi.org/10.3390/ijms22115923

MLA:

Cunningham, Sarah, and Holger Hackstein. "Cord-blood-derived professional antigen-presenting cells: Functions and applications in current and prospective cell therapies." International Journal of Molecular Sciences 22.11 (2021).

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