Stable and selective self-assembly of α-lipoic acid on Ge(001) for biomolecule immobilization
Kazmierczak M, Flesch J, Mitzloff J, Capellini G, Klesse WM, Skibitzki O, You C, Bettenhausen M, Witzigmann B, Piehler J, Schroeder T, Guha S (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 123
Article Number: 175305
Journal Issue: 17
DOI: 10.1063/1.5022532
Abstract
We demonstrate a novel method for the stable and selective surface functionalization of germanium (Ge) embedded in silicon dioxide. The Ge(001) surface is functionalized using α-lipoic acid (ALA), which can potentially be utilized for the immobilization of a wide range of biomolecules. We present a detailed pH-dependence study to establish the effect of the incubation pH value on the adsorption layer of the ALA molecules. A threshold pH value for functionalization is identified, dividing the examined pH range into two regions. Below a pH value of 7, the formation of a disordered ALA multilayer is observed, whereas a stable well-ordered ALA mono- to bi-layer on Ge(001) is achieved at higher pH values. Furthermore, we analyze the stability of the ALA layer under ambient conditions, revealing the most stable functionalized Ge(001) surface to effectively resist oxidation for up to one week. Our established functionalization method paves the way towards the successful immobilization of biomolecules in future Ge-based biosensors.
Authors with CRIS profile
Involved external institutions
Universität Osnabrück
Germany (DE)
Universität Kassel
Germany (DE)
Brandenburgische Technische Universität Cottbus-Senftenberg (BTU)
Germany (DE)
Università degli Studi Roma Tre
Italy (IT)
Germany (DE)
Universität Kassel
Germany (DE)
Brandenburgische Technische Universität Cottbus-Senftenberg (BTU)
Germany (DE)
Università degli Studi Roma Tre
Italy (IT)
How to cite
APA:
Kazmierczak, M., Flesch, J., Mitzloff, J., Capellini, G., Klesse, W.M., Skibitzki, O.,... Guha, S. (2018). Stable and selective self-assembly of α-lipoic acid on Ge(001) for biomolecule immobilization. Journal of Applied Physics, 123(17). https://doi.org/10.1063/1.5022532
MLA:
Kazmierczak, M., et al. "Stable and selective self-assembly of α-lipoic acid on Ge(001) for biomolecule immobilization." Journal of Applied Physics 123.17 (2018).
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