Biodegradation-Resistant Multilayers Coated with Gold Nanoparticles. Toward a Tailor-made Artificial Extracellular Matrix

Prokopovic VZ, Vikulina AS, Sustr D, Duschl C, Volodkin D (2016)

Publication Type: Journal article

Publication year: 2016

Journal

ACS Applied Materials and Interfaces American Chemical Society

Book Volume: 8

Pages Range: 24345-24349

Journal Issue: 37

DOI: 10.1021/acsami.6b10095

Abstract

Polymer multicomponent coatings such as multilayers mimic an extracellular matrix (ECM) that attracts significant attention for the use of the multilayers as functional supports for advanced cell culture and tissue engineering. Herein, biodegradation and molecular transport in hyaluronan/polylysine multilayers coated with gold nanoparticles were described. Nanoparticle coating acts as a semipermeable barrier that governs molecular transport into/from the multilayers and makes them biodegradation-resistant. Model protein lysozyme (mimics of ECM-soluble signals) diffuses into the multilayers as fast- and slow-diffusing populations existing in an equilibrium. Such a composite system may have high potential to be exploited as degradation-resistant drug-delivery platforms suitable for cell-based applications.

Authors with CRIS profile

Anna Vikulina

Involved external institutions

Fraunhofer-Institut für Zelltherapie und Immunologie (IZI) DE Germany (DE)

How to cite

APA:

Prokopovic, V.Z., Vikulina, A.S., Sustr, D., Duschl, C., & Volodkin, D. (2016). Biodegradation-Resistant Multilayers Coated with Gold Nanoparticles. Toward a Tailor-made Artificial Extracellular Matrix. ACS Applied Materials and Interfaces, 8(37), 24345-24349. https://doi.org/10.1021/acsami.6b10095

MLA:

Prokopovic, Vladimir Z., et al. "Biodegradation-Resistant Multilayers Coated with Gold Nanoparticles. Toward a Tailor-made Artificial Extracellular Matrix." ACS Applied Materials and Interfaces 8.37 (2016): 24345-24349.

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