Assessment of sorafenib induced changes in tumor perfusion of uveal melanoma metastases with dynamic contrast-enhanced ultrasound (DCE-US)

Wildner D, Heinzerling L, Scheulen ME, Kämpgen E, Schuler G, Strobel D, Janka RM, Neurath M, Sturm J, Knieling F (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Journal of Cancer Research and Clinical Oncology Springer Verlag (Germany)

DOI: 10.1007/s00432-021-03666-8

Abstract

Purpose Dynamic contrast-enhanced ultrasound (DCE-US) was used to monitor early response to sorafenib therapy in patients with liver metastases from uveal melanoma. Methods In total, 21 patients with liver metastases were recruited within a prospective trial and underwent daily sorafenib therapy. DCE-US of a target lesion was performed before initiation of treatment, on day 15 and 56. Two independent blinded investigators performed software analysis for DCE-US parameters and inter-observer-correlation was calculated. Response to treatment was evaluated on day 56. DCE-US parameters were correlated with clinical response and RECIST1.1 criteria. Results Inter-observer-correlation (r) of DCE-US parameters [time-to-peak (TTP), mean-transit-time (MTT), peak intensity (PI), regional blood volume (RBV), regional blood flow (RBF)] at baseline, day 15, and day 56 was highly significant (r-range 0.73-0.97, all p < 0.001). Out of 17 evaluable patients, 12 patients survived day 56 (clinical responders, cRE), whereas, five patients died before day 56 and were classified as non-responders (cNR). TTP values significantly increased in the cRE group 15 days after initiation of treatment for investigator 1 (p = 0.034) and at day 56 for both investigators (p = 0.028/0.028). MTT had increased significantly in the cRE group on day 56 (p = 0.037/0.022). In the cNR group changes for TTP and MTT remained insignificant. Thus, increase of the DCE-US parameters TTP and MTT are associated with response to treatment and prognosis. Conclusion An increase of TTP and MTT at frequent intervals could serve as a surrogate marker for early response evaluation to anti-angiogenic treatment of metastatic uveal melanoma.

Authors with CRIS profile

Dane Wildner Medizinische Fakultät Lucie Heinzerling Department of Dermatology Gerold Schuler Lehrstuhl für Haut- und Geschlechtskrankheiten Deike Strobel Medizinische Fakultät Rolf Matthias Janka Institute of Radiology Markus Neurath Lehrstuhl für Innere Medizin I Jörg Sturm Medizinische Fakultät Ferdinand Knieling Department of Paediatrics and Adolescent Medicine

Involved external institutions

Universitätsklinikum Essen DE Germany (DE)

How to cite

APA:

Wildner, D., Heinzerling, L., Scheulen, M.E., Kämpgen, E., Schuler, G., Strobel, D.,... Knieling, F. (2021). Assessment of sorafenib induced changes in tumor perfusion of uveal melanoma metastases with dynamic contrast-enhanced ultrasound (DCE-US). Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-021-03666-8

MLA:

Wildner, Dane, et al. "Assessment of sorafenib induced changes in tumor perfusion of uveal melanoma metastases with dynamic contrast-enhanced ultrasound (DCE-US)." Journal of Cancer Research and Clinical Oncology (2021).

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