Maagdenberg H, Oosterom N, Zanen J, Gemmati D, Windsor RE, Heil SG, Esperón P, Jabeen S, Ruiz-Argüelles GJ, Zolk O, Hörning S, Sleurs C, Lopéz-Lopéz E, Moreno-Galván M, van den Heuvel-Eibrink MM, Maitland-van der Zee AH, Carleton BC (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Book Volume: 161
Article Number: 103312
DOI: 10.1016/j.critrevonc.2021.103312
Methotrexate (MTX), an important chemotherapeutic agent, is often accompanied with mucositis. The occurrence and severity are unpredictable and show large interindividual variability. In this study, we review and meta-analyze previously studied genetic variants in relation to MTX-induced mucositis. We conducted a systematic search in Medline and Embase. We included genetic association studies of MTX-induced mucositis in cancer patients. A meta-analysis was conducted for single nucleotide polymorphisms (SNPs) for which at least two studies found a statistically significant association. A total of 34 SNPs were associated with mucositis in at least one study of the 57 included studies. Two of the seven SNPs included in our meta-analysis were statistically significantly associated with mucositis: MTHFR c.677C > T (recessive, grade ≥3 vs grade 0–2, OR 2.53, 95 %CI [1.48–4.32], False Discovery Rate[FDR]-corrected p-value 0.011) and MTRR c.66A > G (overdominant, grade ≥1 vs grade 0, OR 2.08, 95 %CI [1.16–3.73], FDR-corrected p-value 0.042).
APA:
Maagdenberg, H., Oosterom, N., Zanen, J., Gemmati, D., Windsor, R.E., Heil, S.G.,... Carleton, B.C. (2021). Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis. Critical Reviews in Oncology Hematology, 161. https://doi.org/10.1016/j.critrevonc.2021.103312
MLA:
Maagdenberg, Hedy, et al. "Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis." Critical Reviews in Oncology Hematology 161 (2021).
BibTeX: Download