Dietary derived propionate regulates pathogenic fibroblast function and ameliorates experimental arthritis and inflammatory tissue priming

Friščić J, Dürholz K, Chen X, Engdahl C, Möller L, Schett G, Zaiss M, Hoffmann M (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Nutrients MDPI

Book Volume: 13

Article Number: 1643

Journal Issue: 5

DOI: 10.3390/nu13051643

Abstract

Short-chain fatty acids are gut-bacteria-derived metabolites that execute important regulatory functions on adaptive immune responses, yet their influence on inflammation driven by innate immunity remains understudied. Here, we show that propionate treatment in drinking water or upon local application into the joint reduced experimental arthritis and lowered inflammatory tissue priming mediated by synovial fibroblasts. On a cellular level, incubation of synovial fibroblasts with propionate or a physiological mixture of short-chain fatty acids interfered with production of inflammatory mediators and migration and induced immune-regulatory fibroblast senescence. Our study suggests that propionate mediates its alleviating effect on arthritis by direct abrogation of local arthritogenic fibroblast function.

Authors with CRIS profile

Kerstin Dürholz Department of Medicine 3 – Rheumatology and Immunology Xi Chen Professur für Translationale Immunologie Georg Schett Lehrstuhl für Innere Medizin III Mario Zaiss Department of Medicine 3 – Rheumatology and Immunology Markus Hoffmann Medizinische Fakultät

Involved external institutions

University of Gothenburg / Göteborgs universitet SE Sweden (SE)

How to cite

APA:

Friščić, J., Dürholz, K., Chen, X., Engdahl, C., Möller, L., Schett, G.,... Hoffmann, M. (2021). Dietary derived propionate regulates pathogenic fibroblast function and ameliorates experimental arthritis and inflammatory tissue priming. Nutrients, 13(5). https://doi.org/10.3390/nu13051643

MLA:

Friščić, Jasna, et al. "Dietary derived propionate regulates pathogenic fibroblast function and ameliorates experimental arthritis and inflammatory tissue priming." Nutrients 13.5 (2021).

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