Management of cutaneous squamous cell carcinoma Vorgehen bei kutanem Plattenepithelkarzinom

Leiter U, Gutzmer R, Alter M, Ulrich C, Meiwes A, Heppt M, Steeb T, Berking C, Lonsdorf AS, Sachse M, Hillen U (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Onkologe Springer Verlag (Germany)

DOI: 10.1007/s00761-021-00938-3

Abstract

Cutaneous squamous cell carcinoma (SCC) is one of the most common cancers of the Caucasian population and accounts for 20% of all skin tumors. An S3 guideline of the German Oncology Guidelines Program has been available since 2019. The diagnosis is based on the clinical examination. Excision and histological confirmation is required for all clinically suspicious lesions to allow prognostic assessment and correct treatment. The therapy of first choice is complete excision with histological control of the surgical margin. In cutaneous SCC with risk factors such as tumor thickness > 6 mm, sentinel lymph node biopsy (SLNB) may be discussed, but there is currently no clear evidence regarding its prognostic and therapeutic relevance. Adjuvant radiotherapy may be considered if there is a high risk of recurrence, radiotherapy should be considered in case of inoperable tumors. For inoperable local or locoregional recurrence, electrochemotherapy can also be indicated. In case of inoperable/or metastasized SCC, the immune checkpoint inhibitor cemiplimab is approved and recommended as the therapy of first choice. In case of contraindications, chemotherapeutics, epidermal growth factor receptor (EGFR) inhibitors or palliative radiotherapy can be used. Since evidence is limited, systemic therapy should preferably be performed in clinical studies. Follow-up should be risk-adapted and includes dermatological examinations supplemented by ultrasound examinations in high-risk patients.

Authors with CRIS profile

Markus Heppt Department of Dermatology Carola Berking Lehrstuhl für Haut- und Geschlechtskrankheiten

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) Universitätsklinikum Tübingen DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Otto-von-Guericke-Universität Magdeburg DE Germany (DE) Universitätsklinikum Heidelberg DE Germany (DE) Vivantes - Netzwerk für Gesundheit GmbH DE Germany (DE) Klinikum Bremerhaven-Reinkenheide DE Germany (DE)

How to cite

APA:

Leiter, U., Gutzmer, R., Alter, M., Ulrich, C., Meiwes, A., Heppt, M.,... Hillen, U. (2021). Management of cutaneous squamous cell carcinoma Vorgehen bei kutanem Plattenepithelkarzinom. Onkologe. https://doi.org/10.1007/s00761-021-00938-3

MLA:

Leiter, U., et al. "Management of cutaneous squamous cell carcinoma Vorgehen bei kutanem Plattenepithelkarzinom." Onkologe (2021).

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