Using alendronic acid coupled fluorescently labelled SM liposomes as a vehicle for bone targeting
Medina OP, Medina TP, Humbert J, Qi B, Baum W, Will O, Damm T, Glueer C (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 26
Pages Range: 6021-6027
Journal Issue: 46
DOI: 10.2174/1381612826666200614175905
Abstract
Background: We recently developed a liposomal nanoparticle system that can be used for drug delivery and simultaneously be monitored by optical or photoacoustic imaging devices. Here we tested the efficacy of alendronate as a homing molecule in SM-liposomes for bone targeting. Methods: Alendronate was immobilized covalently on the liposomal surface and the fluorescent dye indocyanine green was used as a payload in the liposomes. The indocyanine green delivery was analyzed by 3D optical tomography, optical fluorescence scanner, photoacoustic imaging, and by ex-vivo biodistribution studies. Results: The results show that the alendronate, coupled to the liposomal surface, increases sphingomyelin containing liposome targeting up to several-folds. Conclusion: The alendronate targeted liposomes open possibilities for an application in active bone targeting.
Additional Organisation(s)
Involved external institutions
Germany (DE)How to cite
APA:
Medina, O.P., Medina, T.P., Humbert, J., Qi, B., Baum, W., Will, O.,... Glueer, C. (2020). Using alendronic acid coupled fluorescently labelled SM liposomes as a vehicle for bone targeting. Current Pharmaceutical Design, 26(46), 6021-6027. https://dx.doi.org/10.2174/1381612826666200614175905
MLA:
Medina, Oula Penate, et al. "Using alendronic acid coupled fluorescently labelled SM liposomes as a vehicle for bone targeting." Current Pharmaceutical Design 26.46 (2020): 6021-6027.
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