Tryptophan Catabolism to Serotonin and Kynurenine in Women Undergoing in-vitro Fertilization
Bodis J, Sulyok E, Koppan M, Varnagy A, Premusz V, Godony K, Rascher W, Rauh M (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 69
Pages Range: 1-12
Journal Issue: 6
DOI: 10.33549/physiolres.934435
Abstract
This cross-sectional clinical study was designed to explore the impact of tryptophan-kynurenine and tryptophan-serotonin (5-HT) pathways on reproductive performance during in vitro fertilization (IVF). Paired serum and follicular fluid (FF) samples were obtained from 64 consecutive IVF patients. The analysis was done by using LC-MS/MS. Ovarian hyperstimulation resulted in decreased serum tryptophan (p<0.004), 5-HT (p<0.049) and kynurenine (p<0.001). FF levels of tryptophan (R=0.245, p<0.051), kynurenine (R=0.556, p<0.001) and 5-HT (R=0.523, p<0.001) were positively related to their respective serum levels. Clinical pregnancy was associated with higher serum 5-HT (p<0.045) and FF 5-HT (p<0.020) and lower kynurenine to 5-HT ratio (p<0.024). Chemical pregnancy was also positively related to FF 5-HT (R=0.362, p<0.024). Moreover, there was a direct relationship of the number of mature oocytes to the FF 5-HT (R=0.363, p<0.020) but it was inversely related to FF tryptophan to 5-HT and FF kynurenine to 5-HT ratios (R=-0.389, p<0.016 and R=-0.337, p<0.036, respectively). Multivariate logistic regression revealed that the number of mature oocytes was significantly influenced by FF 5-HT (β=0.473, p<0.001). In IVF patients ovarian hyperstimulation results in a reduction of the availability of tryptophan to catabolic pathways to kynurenine and 5-HT. Outcome measures improved significantly when 5-HT predominated over kynurenine.
Authors with CRIS profile
Wolfgang Rascher
Department of Paediatrics and Adolescent Medicine
Manfred Rauh
Department of Paediatrics and Adolescent Medicine
Involved external institutions
Hungary (HU)How to cite
APA:
Bodis, J., Sulyok, E., Koppan, M., Varnagy, A., Premusz, V., Godony, K.,... Rauh, M. (2020). Tryptophan Catabolism to Serotonin and Kynurenine in Women Undergoing in-vitro Fertilization. Physiological Research, 69(6), 1-12. https://doi.org/10.33549/physiolres.934435
MLA:
Bodis, Jozsef, et al. "Tryptophan Catabolism to Serotonin and Kynurenine in Women Undergoing in-vitro Fertilization." Physiological Research 69.6 (2020): 1-12.
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