The CAM Assay as an Alternative In Vivo Model for Drug Testing
Schneider-Stock R, Ribatti D (2021)
Publication Type: Book chapter / Article in edited volumes
Publication year: 2021
Journal
Publisher: Springer Science and Business Media Deutschland GmbH
Edited Volumes: Organotypic Models in Drug Development
Series: Handbook of Experimental Pharmacology
City/Town: Cham
Book Volume: 265
Pages Range: 303-323
DOI: 10.1007/164_2020_375
Abstract
In the last decade, the chicken chorioallantoic membrane (CAM) assay has been re-discovered in cancer research to study the molecular mechanisms of anti-cancer drug effects. Literature about the CAM assay as an alternative in vivo cancer xenograft model according to the 3R principles has exploded in the last 3 years. Following a summary of the basic knowledge about the chicken embryo, we compare advantages and disadvantages with the classical mouse xenograft model, exemplify established and innovative imaging techniques that are used in the CAM model, and give examples of its successful utilization for studying major hallmarks of cancer such as angiogenesis, proliferation, invasion, and metastasis.
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Italy (IT)How to cite
APA:
Schneider-Stock, R., & Ribatti, D. (2021). The CAM Assay as an Alternative In Vivo Model for Drug Testing. In Monika Schäfer-Korting, Silvya Stuchi Maria-Engler, Robert Landsiedel (Eds.), Organotypic Models in Drug Development. (pp. 303-323). Cham: Springer Science and Business Media Deutschland GmbH.
MLA:
Schneider-Stock, Regine, and Domenico Ribatti. "The CAM Assay as an Alternative In Vivo Model for Drug Testing." Organotypic Models in Drug Development. Ed. Monika Schäfer-Korting, Silvya Stuchi Maria-Engler, Robert Landsiedel, Cham: Springer Science and Business Media Deutschland GmbH, 2021. 303-323.
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