Challenges and Opportunities for Real-World Evidence in Metastatic Luminal Breast Cancer

Lüftner D, Hartkopf AD, Lux MP, Overkamp F, Tesch H, Titzmann A, Pöschke P, Wallwiener M, Müller V, Beckmann M, Belleville E, Janni W, Fehm TN, Kolberg HC, Ettl J, Wallwiener D, Schneeweiss A, Brucker SY, Fasching P (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

DOI: 10.1159/000515701

Abstract

Background: The therapeutic armamentarium for patients with metastatic breast cancer is becoming more and more specific. Recommendations from clinical trials are not available for all treatment situations and patient subgroups, and it is therefore important to collect real-world data. Summary: To develop recommendations for up-to-date treatments and participation in clinical trials for patients with metastatic breast cancer, the Prospective Academic Translational Research PRAEGNANT Network was established to optimize the quality of oncological care in the advanced therapeutic setting. The main aim of PRAEGNANT is to systematically record medical care for patients with metastatic breast cancer in the real-life setting, including the outcome and side effects of different treatment strategies, to monitor quality-of-life changes during therapy, to identify patients eligible for participation in clinical studies, and to allow targeted therapies based on the molecular structures of breast carcinomas. Key Messages: This article describes the PRAEGNANT network and sheds light on the question of whether the various end points from clinical trials can be transferred to the real-world treatment situation.

Authors with CRIS profile

Involved external institutions

Ruprecht-Karls-Universität Heidelberg Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) ClinSol GmbH & Co.KG Germany (DE) Eberhard Karls Universität Tübingen Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) St.-Josefs-Krankenhaus Hilden Germany (DE) OncoConsult Germany (DE) Agaplesion Markus Krankenhaus Germany (DE) Universitätsklinikum Ulm Germany (DE) Universitätsklinikum Düsseldorf Germany (DE) Marienhospital Bottrop Germany (DE) Klinikum rechts der Isar Germany (DE)

How to cite

APA:

Lüftner, D., Hartkopf, A.D., Lux, M.P., Overkamp, F., Tesch, H., Titzmann, A.,... Fasching, P. (2021). Challenges and Opportunities for Real-World Evidence in Metastatic Luminal Breast Cancer. Breast Care. https://doi.org/10.1159/000515701

MLA:

Lüftner, Diana, et al. "Challenges and Opportunities for Real-World Evidence in Metastatic Luminal Breast Cancer." Breast Care (2021).

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