Arming immune cells for battle: A brief journey through the advancements of t and nk cell immunotherapy

Wendel P, Reindl LM, Bexte T, Künnemeyer L, Särchen V, Albinger N, Mackensen A, Rettinger E, Bopp T, Ullrich E (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Cancers MDPI

Book Volume: 13

Article Number: 1481

Journal Issue: 6

DOI: 10.3390/cancers13061481

Abstract

The promising development of adoptive immunotherapy over the last four decades has revealed numerous therapeutic approaches in which dedicated immune cells are modified and ad-ministered to eliminate malignant cells. Starting in the early 1980s, lymphokine activated killer (LAK) cells were the first ex vivo generated NK cell‐enriched products utilized for adoptive immu-notherapy. Over the past decades, various immunotherapies have been developed, including cyto-kine‐induced killer (CIK) cells, as a peripheral blood mononuclear cells (PBMCs)‐based therapeutic product, the adoptive transfer of specific T and NK cell products, and the NK cell line NK‐92. In addition to allogeneic NK cells, NK‐92 cell products represent a possible “off‐the‐shelf” therapeutic concept. Recent approaches have successfully enhanced the specificity and cytotoxicity of T, NK, CIK or NK‐92 cells towards tumor‐specific or associated target antigens generated by genetic engineering of the immune cells, e.g., to express a chimeric antigen receptor (CAR). Here, we will look into the history and recent developments of T and NK cell‐based immunotherapy.

Authors with CRIS profile

Andreas Mackensen Lehrstuhl für Innere Medizin V

Involved external institutions

Goethe-Universität Frankfurt am Main DE Germany (DE) Universitätsmedizin der Johannes Gutenberg-Universität Mainz DE Germany (DE)

How to cite

APA:

Wendel, P., Reindl, L.M., Bexte, T., Künnemeyer, L., Särchen, V., Albinger, N.,... Ullrich, E. (2021). Arming immune cells for battle: A brief journey through the advancements of t and nk cell immunotherapy. Cancers, 13(6). https://doi.org/10.3390/cancers13061481

MLA:

Wendel, Philipp, et al. "Arming immune cells for battle: A brief journey through the advancements of t and nk cell immunotherapy." Cancers 13.6 (2021).

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