Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer 1 Fertility preservation for female patients with childhood , adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Mulder RL, Font-Gonzalez A, Hudson MM, Santen HMV, Loeffen EAH, Burns KC, Quinn GP, Broeder EVDD, Byrne J, Haupt R, Wallace WH, Heuvel-Eibrink MMVD, Anazodo A, Anderson RA, Barnbrock A, Beck JD, Bos AME, Demeestere I, Denzer C, Iorgi ND, Hoefgen HR, Kebudi R, Lambalk C, Langer T, Meacham LR, Rodriguez-Wallberg K, Stern C, Stutz-Grunder E, Dorp WV, Veening M, Veldkamp S, Meulen EVD, Constine LS, Kenney LB, Wetering MDVD, Kremer LCM, Levine J, Tissing WJE (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Book Volume: 22

Pages Range: E45-E56

Journal Issue: 2

Abstract

Female patients with childhood, adolescent, and young adult cancer are at increased risk for fertility impairment when treatment adversely affects the function of reproductive organs. Patients and their families desire biological children but substantial variations in clinical practice guidelines reduce consistent and timely implementation of effective interventions for fertility preservation across institutions. As part of the PanCareLIFE Consortium, and in collaboration with the International Late Effects of Childhood Cancer Guideline Harmonization Group, we reviewed the current literature and developed a clinical practice guideline for fertility preservation in female patients who were diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger, including guidance on risk assessment and available methods for fertility preservation. The Grading of Recommendations Assessment, Development and Evaluation methodology was used to grade the available evidence and to form the recommendations. This clinical practice guideline leverages existing evidence and international expertise to develop transparent recommendations that are easy to use to facilitate the care of female patients with childhood, adolescent, and young adult cancer who are at high risk for fertility impairment. A complete review of the existing evidence, including a quality assessment, transparent reporting of the guideline panel's decisions, and achievement of global interdisciplinary consensus, is an important result of this intensive collaboration.

Authors with CRIS profile

Involved external institutions

University of Amsterdam Netherlands (NL) Dutch Childhood Cancer Parent Organisation (VOKK) / Vereniging Ouders, Kinderen en Kanker (VOKK) Netherlands (NL) University of Groningen / Rijksuniversiteit Groningen Netherlands (NL) Cornell University United States (USA) (US) Harvard University United States (USA) (US) University of Rochester (UR) United States (USA) (US) Istanbul University Cerrahpaşa / İstanbul Üniversitesi Cerrahpaşa (IUC) Turkey (TR) Children's Healthcare of Atlanta Inc. United States (USA) (US) Wilhelmina Kinderziekenhuis Netherlands (NL) University of Genova / Università degli Studi di Genova Italy (IT) Erasmus University Medical Center (MC) Netherlands (NL) Royal Hospital for Sick Children United Kingdom (GB) Cincinnati Children's Hospital Medical Center United States (USA) (US) Boyne Research Institute Ireland (IE) Istituto Giannina Gaslini Italy (IT) University Medical Centre Utrecht (UMC Utrecht) Netherlands (NL) Melbourne IVF Australia (AU) Washington University in St. Louis United States (USA) (US) Sydney Children’s Hospitals Network Australia (AU) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) Vrije Universiteit Amsterdam (VU) / University Amsterdam Netherlands (NL) St. Jude Children’s Research Hospital United States (USA) (US) Université libre de Bruxelles (ULB) / Free University of Brussels Belgium (BE) Universitätsklinikum Schleswig-Holstein (UKSH) Germany (DE) University of Edinburgh United Kingdom (GB) New York University (NYU) United States (USA) (US) Goethe-Universität Frankfurt am Main Germany (DE) University of Zurich / Universität Zürich (UZH) Switzerland (CH) Universität Ulm Germany (DE)

How to cite

APA:

Mulder, R.L., Font-Gonzalez, A., Hudson, M.M., Santen, H.M.V., Loeffen, E.A.H., Burns, K.C.,... Tissing, W.J.E. (2021). Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer 1 Fertility preservation for female patients with childhood , adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncology, 22(2), E45-E56.

MLA:

Mulder, Renee L., et al. "Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer 1 Fertility preservation for female patients with childhood , adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group." Lancet Oncology 22.2 (2021): E45-E56.

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