Paediatric chronic myeloid leukaemia presenting in de novo or secondary blast phase - a comparison of clinical and genetic characteristics

Sembill S, Goehring G, Schirmer E, Lutterloh F, Suttorp M, Metzler M, Karow A (2021)

Publication Type: Journal article

Publication year: 2021

Journal

British Journal of Haematology Wiley-Blackwell

DOI: 10.1111/bjh.17378

Abstract

Additional data on blast phase (BP) chronic myeloid leukaemia (CML) in children and adolescents is essential for improving diagnostic and therapeutic approaches of this rare but serious condition. Here, we describe distinct clinical and genetic characteristics of 18 paediatric patients with de novo (n = 10) and secondary (n = 8) BP CML enrolled in the CML-PAED-II trial and registry. Our findings suggest that paediatric patients exhibit a diverse cytogenetic profile compared to adults with BP CML. In addition, patients with de novo BP CML in this cohort presented at a younger age, whereas patients with secondary BP CML more often harboured complex karyotypes.

Authors with CRIS profile

Markus Metzler Professur für Kinder- und Jugendmedizin mit dem Schwerpunkt Pädiatrische Onkologie und Hämatologie

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) Technische Universität Dresden DE Germany (DE)

How to cite

APA:

Sembill, S., Goehring, G., Schirmer, E., Lutterloh, F., Suttorp, M., Metzler, M., & Karow, A. (2021). Paediatric chronic myeloid leukaemia presenting in de novo or secondary blast phase - a comparison of clinical and genetic characteristics. British Journal of Haematology. https://doi.org/10.1111/bjh.17378

MLA:

Sembill, Stephanie, et al. "Paediatric chronic myeloid leukaemia presenting in de novo or secondary blast phase - a comparison of clinical and genetic characteristics." British Journal of Haematology (2021).

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