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Cost-effectiveness of digital breast tomosynthesis vs. Abbreviated breast mri for screening women with intermediate risk of breast cancer—how low-cost must mri be?

Tollens F, Baltzer PA, Dietzel M, Rübenthaler J, Froelich MF, Kaiser CG (2021)

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Publication Type: Journal article

Publication year: 2021

Journal

Book Volume: 13

Pages Range: 1-14

Article Number: 1241

Journal Issue: 6

DOI: 10.3390/cancers13061241

Abstract

Background: Digital breast tomosynthesis (DBT) and abbreviated breast MRI (AB-MRI) offer superior diagnostic performance compared to conventional mammography in screening women with intermediate risk of breast cancer due to dense breast tissue. The aim of this model-based economic evaluation was to analyze whether AB-MRI is cost-effective in this cohort compared to DBT. Methods: Decision analysis and Markov simulations were used to model the cumulative costs and quality-adjusted life-years (QALYs) over a time horizon of 30 years. Model input parameters were adopted from recent literature. Deterministic and probabilistic sensitivity analyses were applied to test the stability of the model. Results: In the base-case scenario, the costs of an AB-MRI examination were defined to equal the costs of a full protocol acquisition. Two-yearly screening of women with dense breasts resulted in cumulative discounted costs of $8798 and $9505 for DBT and AB-MRI, and cumulative discounted effects of 19.23 and 19.27 QALYs, respectively, with an incremental cost-effectiveness ratio of $20,807 per QALY gained in the base-case scenario. By reducing the cost of an AB-MRI examination below a threshold of $241 in sensitivity analyses, AB-MRI would become cost-saving compared to DBT. Conclusion: In comparison to DBT, AB-MRI can be considered cost-effective up to a price per examination of $593 in screening patients at intermediate risk of breast cancer.

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How to cite

APA:

Tollens, F., Baltzer, P.A., Dietzel, M., Rübenthaler, J., Froelich, M.F., & Kaiser, C.G. (2021). Cost-effectiveness of digital breast tomosynthesis vs. Abbreviated breast mri for screening women with intermediate risk of breast cancer—how low-cost must mri be? Cancers, 13(6), 1-14. https://doi.org/10.3390/cancers13061241

MLA:

Tollens, Fabian, et al. "Cost-effectiveness of digital breast tomosynthesis vs. Abbreviated breast mri for screening women with intermediate risk of breast cancer—how low-cost must mri be?" Cancers 13.6 (2021): 1-14.

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