Radiosynthesis and evaluation of F-18-labeled dopamine D-4-receptor ligands

Willmann M, Ermert J, Prante O, Hübner H, Gmeiner P, Neumaier B (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Nuclear Medicine and Biology Elsevier

Book Volume: 92

Pages Range: 43-52

DOI: 10.1016/j.nucmedbio.2020.07.004

Abstract

Introduction: The dopamine D-4 receptor (D4R) has attracted considerable attention as potential target for the treatment of a broad range of central nervous system disorders. Although many efforts have been made to improve the performance of putative radioligand candidates, there is still a lack of D4R selective tracers suitable for in vivo PET imaging. Thus, the objective of this work was to develop a D-4-selective PET ligand for clinical applications.

Authors with CRIS profile

Olaf Prante Professur für Molekulare Bildgebung und Radiochemie Harald Hübner Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie

Involved external institutions

Forschungszentrum Jülich / Research Centre Jülich (FZJ) DE Germany (DE)

How to cite

APA:

Willmann, M., Ermert, J., Prante, O., Hübner, H., Gmeiner, P., & Neumaier, B. (2021). Radiosynthesis and evaluation of F-18-labeled dopamine D-4-receptor ligands. Nuclear Medicine and Biology, 92, 43-52. https://doi.org/10.1016/j.nucmedbio.2020.07.004

MLA:

Willmann, Michael, et al. "Radiosynthesis and evaluation of F-18-labeled dopamine D-4-receptor ligands." Nuclear Medicine and Biology 92 (2021): 43-52.

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