Domination of volumetric toughening by silver nanoparticles over interfacial strengthening of carbon nanotubes in bactericidal hydroxyapatite biocomposite

Herkendell K, Shukla VR, Patel AK, Balani K (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Materials Science and Engineering C Elsevier

Book Volume: 34

Pages Range: 455-467

Journal Issue: 1

DOI: 10.1016/j.msec.2013.09.034

Abstract

In order to address the problem of bacterial infections in bone-substitution surgery, it is essential that bone replacement biomaterials are equipped with bactericidal components. This research aims to optimize the content of silver (Ag), a well-known antibacterial metal, in a multiwalled carbon nanotube (CNT) reinforced hydroxyapatite (HA) composite, to yield a bioceramic which can be used as an antibacterial and tough surface of bone replacement prosthesis. The bactericidal properties evaluated using Escherichia coli and Staphylococcus epidermidis indicate that CNT reinforcement supports growth of Gram negative E. coli bacteria (~ 8.5% more adhesion than pure HA); but showed a strong decrease of Gram positive S. epidermidis bacteria (~ diminished to 66%) compared to that of pure HA. Small amounts of silver (2-5 wt.%) already show a severe bactericidal effect when compared to that of HA-CNT (by 30% and ~ 60% respectively). MTT assay confirmed enhanced biocompatibility of L929 cells on HA-4 wt.% CNT (~ 121%), HA-4 wt.% CNT-1 wt.% Ag (~ 124%) sample and HA-4 wt.% CNT-2 wt.% Ag (~ 100%) when compared to that of pure HA. The samples with higher silver content showed decreased biocompatibility (77% for HA-4 wt.% CNT-5 wt.% Ag sample and 73% for HA-4 wt.% CNT-10 wt.% Ag). Though reinforcement of 4 wt.% CNT has shown an increase of fracture toughness by ~ 62%, silver reinforcement has shown enhancement of up to 244% (i.e. 3.43 times). Accordingly, isolation of toughening contribution indicates that volumetric toughening by silver dominates over interfacial strengthening contributed by CNTs towards enhanced fracture toughness of potential HA-Ag-CNT biocomposites. © 2013 Elsevier B.V.

Authors with CRIS profile

Katharina Herkendell

Involved external institutions

Indian Institute of Technology Kanpur (IITK) IN India (IN) Karlsruhe Institute of Technology (KIT) DE Germany (DE)

How to cite

APA:

Herkendell, K., Shukla, V.R., Patel, A.K., & Balani, K. (2014). Domination of volumetric toughening by silver nanoparticles over interfacial strengthening of carbon nanotubes in bactericidal hydroxyapatite biocomposite. Materials Science and Engineering C, 34(1), 455-467. https://dx.doi.org/10.1016/j.msec.2013.09.034

MLA:

Herkendell, Katharina, et al. "Domination of volumetric toughening by silver nanoparticles over interfacial strengthening of carbon nanotubes in bactericidal hydroxyapatite biocomposite." Materials Science and Engineering C 34.1 (2014): 455-467.

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