Definition, epidemiology, pathophysiology, and essential criteria for diagnosis of pediatric chronic myeloid leukemia

Suttorp M, Sembill S, Deutsch H, Metzler M, Millot F (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Cancers MDPI

Book Volume: 13

Pages Range: 1-21

Article Number: 798

Journal Issue: 4

DOI: 10.3390/cancers13040798

Abstract

Depending on the analytical tool applied, the hallmarks of chronic myeloid leukemia (CML) are the Philadelphia Chromosome and the resulting mRNA fusion transcript BCR-ABL1. With an incidence of 1 per 1 million of children this malignancy is very rare in the first 20 years of life. This article aims to; (i) define the disease based on the WHO nomenclature, the appropriate ICD 11 code and to unify the terminology, (ii) delineate features of epidemiology, etiology, and pathophysiology that are shared, but also differing between adult and pediatric patients with CML, iii) give a short summary on the diseases to be considered as a differential diagnosis of pediatric CML, (iv) to describe the morphological, histopathological and immunophenotypical findings of CML in pediatric patients, (v) illustrate rare but classical complications resulting from rheological problems observed at diagnosis, (vi) list essential and desirable diagnostic criteria, which hopefully in the future will help to unify the attempts when approaching this rare pediatric malignancy.

Authors with CRIS profile

Markus Metzler Professur für Kinder- und Jugendmedizin mit dem Schwerpunkt Pädiatrische Onkologie und Hämatologie

Involved external institutions

Centre hospitalier universitaire de Poitiers (CHU de Poitiers) FR France (FR) Technische Universität Dresden DE Germany (DE)

How to cite

APA:

Suttorp, M., Sembill, S., Deutsch, H., Metzler, M., & Millot, F. (2021). Definition, epidemiology, pathophysiology, and essential criteria for diagnosis of pediatric chronic myeloid leukemia. Cancers, 13(4), 1-21. https://doi.org/10.3390/cancers13040798

MLA:

Suttorp, Meinolf, et al. "Definition, epidemiology, pathophysiology, and essential criteria for diagnosis of pediatric chronic myeloid leukemia." Cancers 13.4 (2021): 1-21.

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