Adult-onset Still's disease and chronic recurrent multifocal osteomyelitis: A hitherto undescribed manifestation of autoinflammation

Rech J, Manger B, Lang B, Schett G, Wilhelm M, Birkmann J (2012)

Publication Type: Journal article

Publication year: 2012

Journal

Rheumatology International Springer Verlag (Germany)

Book Volume: 32

Pages Range: 1827-1829

Journal Issue: 6

DOI: 10.1007/s00296-011-2020-x

Abstract

Still's disease and chronic recurrent multifocal osteomyelitis (CRMO) are febrile rheumatic diseases of unknown etiology, which predominantly affect children but can also have their initial manifestation in adults. Both can present as intermittent, relapsing episodes and are considered potential candidates within the expanding spectrum of autoinflammatory disorders, although no genetic abnormalities have been described for either of them. Here, we describe a man with an initial manifestation of abacterial multifocal osteitis at the age of 41. During a relapsing- remitting course of his illness, he increasingly developed symptoms of adult-onset Still's disease (AOSD), and the diagnosis was established according to the Yamaguchi criteria. When treated with anakinra, not only the acute symptoms disappeared promptly, but also the osteitis went into complete remission. This is to our knowledge the first description of a simultaneous occurrence of these two manifestations of autoinflammation in adulthood. © Springer-Verlag 2011.

Authors with CRIS profile

Hans Jürgen Rech Department of Medicine 3 – Rheumatology and Immunology Bernhard Manger Professur für Rheumatologie und Klinische Immunologie Georg Schett Lehrstuhl für Innere Medizin III

Involved external institutions

Klinikum Nürnberg DE Germany (DE)

How to cite

APA:

Rech, J., Manger, B., Lang, B., Schett, G., Wilhelm, M., & Birkmann, J. (2012). Adult-onset Still's disease and chronic recurrent multifocal osteomyelitis: A hitherto undescribed manifestation of autoinflammation. Rheumatology International, 32(6), 1827-1829. https://doi.org/10.1007/s00296-011-2020-x

MLA:

Rech, Jürgen, et al. "Adult-onset Still's disease and chronic recurrent multifocal osteomyelitis: A hitherto undescribed manifestation of autoinflammation." Rheumatology International 32.6 (2012): 1827-1829.

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