cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis

Worrell JC, Leslie J, Smith GR, Zaki MYW, Paish HL, Knox A, James ML, Cartwright TN, O'Reilly S, Kania G, Distler O, Distler J, Herrick AL, Jeziorska M, Borthwick LA, Fisher AJ, Mann J, Mann DA, Oakley F (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Rheumatology Oxford University Press

Book Volume: 59

Pages Range: 3939-3951

Journal Issue: 12

DOI: 10.1093/rheumatology/keaa272

Abstract

Objectives. NF-kappa B regulates genes that control inflammation, cell proliferation, differentiation and survival. Dysregulated NF-kappa B signalling alters normal skin physiology and deletion of cRel limits bleomycin-induced skin fibrosis. This study investigates the role of cRel in modulating fibroblast phenotype in the context of SSc.

Authors with CRIS profile

Jörg Distler Professur für Molekulare Mechanismen der Organfibrose

Involved external institutions

Newcastle University

United Kingdom (GB) Northumbria University

United Kingdom (GB) Universitätsspital Zürich (USZ)

Switzerland (CH) University of Manchester

United Kingdom (GB)

How to cite

APA:

Worrell, J.C., Leslie, J., Smith, G.R., Zaki, M.Y.W., Paish, H.L., Knox, A.,... Oakley, F. (2020). cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis. Rheumatology, 59(12), 3939-3951. https://doi.org/10.1093/rheumatology/keaa272

MLA:

Worrell, Julie C., et al. "cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis." Rheumatology 59.12 (2020): 3939-3951.

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