Transport of L-Arginine Related Cardiovascular Risk Markers
Banjarnahor S, Rodionov RN, König J, Maas R (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
Book Volume: 9
Journal Issue: 12
DOI: 10.3390/jcm9123975
Abstract
L-arginine and its derivatives, asymmetric and symmetric dimethylarginine (ADMA and SDMA) and L-homoarginine, have emerged as cardiovascular biomarkers linked to cardiovascular outcomes and various metabolic and functional pathways such as NO-mediated endothelial function. Cellular uptake and efflux of L-arginine and its derivatives are facilitated by transport proteins. In this respect the cationic amino acid transporters CAT1 and CAT2 (SLC7A1 and SLC7A2) and the system y(+)L amino acid transporters (SLC7A6 and SLC7A7) have been most extensively investigated, so far, but the number of transporters shown to mediate the transport of L-arginine and its derivatives is constantly increasing. In the present review we assess the growing body of evidence regarding the function, expression, and clinical relevance of these transporters and their possible relation to cardiovascular diseases.
Authors with CRIS profile
Sofna Banjarnahor
Professur für Arzneimitteltherapiesicherheit und Klinische Pharmakologie
Jörg König
Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie
Renke Maas
Professur für Arzneimitteltherapiesicherheit und Klinische Pharmakologie
Involved external institutions
Germany (DE)How to cite
APA:
Banjarnahor, S., Rodionov, R.N., König, J., & Maas, R. (2020). Transport of L-Arginine Related Cardiovascular Risk Markers. Journal of Clinical Medicine, 9(12). https://doi.org/10.3390/jcm9123975
MLA:
Banjarnahor, Sofna, et al. "Transport of L-Arginine Related Cardiovascular Risk Markers." Journal of Clinical Medicine 9.12 (2020).
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