Regulation of the humoral type 2 immune response against allergens and helminths

Haase P, Vöhringer D (2020)


Publication Type: Journal article, Review article

Publication year: 2020

Journal

DOI: 10.1002/eji.202048864

Abstract

The type 2 immune response is associated with helminth infections and allergic inflammation where antibody production of the IgG1 and IgE isotypes can elicit protective or proinflammatory functions. Studies over the past few years revealed important new insights regarding the regulatory mechanisms orchestrating the humoral type 2 immune response. This includes investigations on B-cell extrinsic signals, such IL-4 and IL-21, derived from different T-helper cell subsets or discovery of new follicular helper T cells with regulatory or IgE-promoting activities. In addition, studies on B-cell intrinsic factors required for germinal center formation and class switch recombination, including the transcription factors STAT3, STAT6, and BCL-6, led to a better understanding of these processes in type 2 immune responses. Here, we review the current understanding of mechanisms controlling humoral type 2 immunity in vivo including the generation of IgE-producing plasma cells and the memory IgE response.

Authors with CRIS profile

How to cite

APA:

Haase, P., & Vöhringer, D. (2020). Regulation of the humoral type 2 immune response against allergens and helminths. European Journal of Immunology. https://doi.org/10.1002/eji.202048864

MLA:

Haase, Paul, and David Vöhringer. "Regulation of the humoral type 2 immune response against allergens and helminths." European Journal of Immunology (2020).

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