Scoring osteoarthritis reliably in large joints and the spine using whole-body ct: Osteoarthritis computed tomography-score (oact-score)

Gielis WP, Weinans H, Nap FJ, Roemer F, Foppen W (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Journal of Personalized Medicine MDPI

Book Volume: 11

Pages Range: 1-13

Article Number: 5

Journal Issue: 1

DOI: 10.3390/jpm11010005

Abstract

A standardized method to assess structural osteoarthritis (OA) burden thorough the body lacks from literature. Such a method can be valuable in developing personalized treatments for OA. We developed a reliable scoring system to evaluate OA in large joints and the spine—the OsteoArthritis Computed Tomography (OACT) score, using a convenience sample of 197 whole-body low-dose non-contrast CTs. An atlas, containing example images as reference points for training and scoring, are presented. Each joint was graded between 0–3. The total OA burden was calculated by summing scores of individual joints. Intra-and inter-observer reliability was tested 25 randomly selected scans (N = 600 joints). Intra-observer reliability and inter-observer reliability between three observers was assessed using intraclass correlation coefficient (ICC) and square-weighted kappa statistics. The square-weighted kappa for intra-observer reliability for OACT-score at joint-level ranged from 0.79 to 0.95; the ICC for the total OA grade was 0.97 (95%-CI, 0.94 to 0.99). Square-weighted kappa for interobserver reliability ranged from 0.48 to 0.95; the ICC for the total OA grade was 0.95 (95%-CI, 0.90 to 0.98). The OACT score, a new reproducible CT-based grading system reflecting OA burden in large joints and the spine, has a satisfactory reproducibility. The atlas can be used for research purposes, training, educational purposes and systemic grading of OA on CT-scans.

Authors with CRIS profile

Frank Roemer Institute of Radiology

Involved external institutions

University Medical Centre Utrecht (UMC Utrecht) NL Netherlands (NL) Centraal Militair Hospitaal (CMH) NL Netherlands (NL)

How to cite

APA:

Gielis, W.P., Weinans, H., Nap, F.J., Roemer, F., & Foppen, W. (2021). Scoring osteoarthritis reliably in large joints and the spine using whole-body ct: Osteoarthritis computed tomography-score (oact-score). Journal of Personalized Medicine, 11(1), 1-13. https://doi.org/10.3390/jpm11010005

MLA:

Gielis, Willem Paul, et al. "Scoring osteoarthritis reliably in large joints and the spine using whole-body ct: Osteoarthritis computed tomography-score (oact-score)." Journal of Personalized Medicine 11.1 (2021): 1-13.

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