Synthesis of Isoxazolylvinyl Ketones from Substituted Furans

Serdyuk O, Hampel F, Abaev VT (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Chemistry of Heterocyclic Compounds Springer Verlag (Germany)

DOI: 10.1007/s10593-020-02841-y

Abstract

[Figure not available: see fulltext.] A new method for the preparation of isoxazolylvinyl ketones related to potential cytotoxic agents has been developed. In the first step, the reaction of furfuryl ketones with hydroxylamine hydrochloride affords the corresponding oximes. Further, the oxidative ring opening – ring closure reaction of oximes leads to isoxazoles with an α, β-unsaturated carbonyl motif. The developed procedure is metal-free and does not require expensive starting materials.

Authors with CRIS profile

Olga Serdyuk Lehrstuhl für Pharmazeutische Chemie Frank Hampel Lehrstuhl für Organische Chemie I

Involved external institutions

North Ossetian State University RU Russian Federation (RU)

How to cite

APA:

Serdyuk, O., Hampel, F., & Abaev, V.T. (2020). Synthesis of Isoxazolylvinyl Ketones from Substituted Furans. Chemistry of Heterocyclic Compounds. https://doi.org/10.1007/s10593-020-02841-y

MLA:

Serdyuk, Olga, Frank Hampel, and Vladimir T. Abaev. "Synthesis of Isoxazolylvinyl Ketones from Substituted Furans." Chemistry of Heterocyclic Compounds (2020).

BibTeX: Download