Lateral patellar tilt and its longitudinal association with patellofemoral osteoarthritis-related structural damage: Analysis of the osteoarthritis initiative data

Zikria B, Rinaldi J, Guermazi A, Haj-Mirzaian A, Pishgar F, Roemer F, Hakky M, Sereni C, Demehri S (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Knee Elsevier

Book Volume: 27

Pages Range: 1971-1979

Journal Issue: 6

DOI: 10.1016/j.knee.2020.11.002

Abstract

Background: Increase in lateral patellar tilt-(LPT) can cause increased pressure on the lateral facet of the knee and can lead to patellar or femoral cartilage damage and further osseous changes. This study aims to test the hypothesis whether there is an association between increased LPT and MRI-based patellofemoral osteoarthritis-(OA) features at baseline and their worsening over a 2-year follow-up in participants of the Osteoarthritis Initiative-(OAI). Methods: Recorded clinical and imaging data of 600 participants in the FNIH-OA biomarkers consortium was extracted from its database. The LPT-(as the angle between the longest patella diameter and posterior aspect of condyles) was measured using the axial knee MRI. Associations of LPT (every 5° increase) with MRI OA Knee Scoring-(MOAKS) for OA-related features, including cartilage and bone marrow lesions (BMLs) in addition to knee cartilage volume at baseline and their worsening after 2-year follow-up were assessed using regression models adjusted for several possible confounders. Results: The mean LPT angle in this sample was 8.84° ± 5.19. In baseline, higher LPT was associated with lower cartilage volumes and higher cartilage lesions and BMLs MOAKS scores in the lateral trochlear and patellar subregions. Over the follow-ups, subjects with higher LPT measures in the baseline showed higher odds of experiencing BML score worsening in the lateral trochlear subregion-(OR:1.25[1.01–1.56]) over the 2-year follow-ups. Conclusions: Increase in LPT measures may be associated with OA-related features in the trochlear subregion. Therefore, aside from its use as an indicator of patellofemoral instability syndrome, LPT may be associated with longitudinal progression of patellofemoral OA.

Authors with CRIS profile

Frank Roemer Institute of Radiology

Involved external institutions

Boston Medical Center (BMC) US United States (USA) (US) Johns Hopkins University (JHU) US United States (USA) (US) University of Massachusetts Medical School US United States (USA) (US) Florida International University US United States (USA) (US)

How to cite

APA:

Zikria, B., Rinaldi, J., Guermazi, A., Haj-Mirzaian, A., Pishgar, F., Roemer, F.,... Demehri, S. (2020). Lateral patellar tilt and its longitudinal association with patellofemoral osteoarthritis-related structural damage: Analysis of the osteoarthritis initiative data. Knee, 27(6), 1971-1979. https://doi.org/10.1016/j.knee.2020.11.002

MLA:

Zikria, Bashir, et al. "Lateral patellar tilt and its longitudinal association with patellofemoral osteoarthritis-related structural damage: Analysis of the osteoarthritis initiative data." Knee 27.6 (2020): 1971-1979.

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