Jahn T, Clark C, Kerksiek A, Lewczuk P, Lütjohann D, Popp J (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 205
Article Number: 105785
DOI: 10.1016/j.jsbmb.2020.105785
Background and Purpose: Altered cholesterol metabolism is associated with increased risk of neurodegeneration and in particular with the development of Alzheimer's disease (AD). Here, we investigate whether non-cholesterol sterols and oxysterols in the central nervous system are associated with (i) the presence of cerebral AD pathology, (ii) distinct aspects of AD pathology, i.e. amyloid pathology, neuronal injury, and tau pathology, and (iii) cognitive decline over time. Experimental Approach: One hundred forty-two elder subjects with normal cognition, mild cognitive impairment, or mild dementia participating in a cohort study on cognitive decline and AD were included. Clinical and neuropsychological assessments were performed at inclusion and repeated at follow-up visits at 18 and 36 months. Concentrations of cholesterol, non-cholesterol sterols, and cholesterol metabolites were measured in cerebrospinal fluid (CSF), along with CSF beta-amyloid (Aβ)
APA:
Jahn, T., Clark, C., Kerksiek, A., Lewczuk, P., Lütjohann, D., & Popp, J. (2021). Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer's cerebral pathology and clinical disease progression. Journal of Steroid Biochemistry and Molecular Biology, 205. https://doi.org/10.1016/j.jsbmb.2020.105785
MLA:
Jahn, Tabea, et al. "Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer's cerebral pathology and clinical disease progression." Journal of Steroid Biochemistry and Molecular Biology 205 (2021).
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