The role of metabolic and haemodynamic factors in podocyte injury in diabetes
Stieger N, Worthmann K, Schiffer M (2011)
Publication Type: Journal article, Review article
Publication year: 2011
Journal
Book Volume: 27
Pages Range: 207-215
Journal Issue: 3
DOI: 10.1002/dmrr.1164
Abstract
Podocyte loss is a common feature in human diabetes as well as in experimental diabetes in rodents. Almost all components of the diabetic milieu lead to serious podocyte stress, driving the cells towards cell cycle arrest and hypertrophy, detachment and apoptosis. Common pathway components induced by high glucose and advanced glycation endproducts are reactive oxygen species, cyclin-dependent kinases (p27$^{\rm{Kip1}}$) and transforming growth factor-beta. In addition, mechanical stresses by stretch or shear forces, insulin deficiency or insulin resistance are independent components resulting in podocyte apoptosis and detachment. In this review, we discuss the common pathways leading to podocyte death as well as novel pathways and concepts of podocyte dedifferentiation and detachment that influence the progression of diabetic glomerulopathy. © 2011 John Wiley & Sons, Ltd..
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Germany (DE)How to cite
APA:
Stieger, N., Worthmann, K., & Schiffer, M. (2011). The role of metabolic and haemodynamic factors in podocyte injury in diabetes. Diabetes-Metabolism Research and Reviews, 27(3), 207-215. https://doi.org/10.1002/dmrr.1164
MLA:
Stieger, Nicole, Kirstin Worthmann, and Mario Schiffer. "The role of metabolic and haemodynamic factors in podocyte injury in diabetes." Diabetes-Metabolism Research and Reviews 27.3 (2011): 207-215.
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