The podocyte power-plant disaster and its contribution to glomerulopathy

Müller-Deile J, Schiffer M (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Frontiers in Endocrinology Frontiers Media

Book Volume: 5

Article Number: 209

Journal Issue: DEC

DOI: 10.3389/fendo.2014.00209

Abstract

Proper podocyte function within the glomerulus demands a high and continuous energy supply that is mainly derived from the respiratory chain of the inner mitochondrial membrane. Dysregulations in the metabolic homeostasis of podocytes may result in podocyte damage and glomerular disease. This article highlights the current knowledge about podocyte energy supply by the respiratory chain. We review the regulation of mitochondrial oxidative metabolism with regard to podocytopathy and discuss the latest understanding of different mitochondrial dysfunctions of the podocyte in diabetic nephropathy and focal segmental glomerulosclerosis (FSGS). We discuss genetic forms of mitochondriopathy of the podocyte and end with recent knowledge about crosstalk between NADH and NADPH and potential therapeutic options for podocyte mitochondriopathy. We aim to raise awareness for the complex and interesting mechanisms of podocyte damage by impaired energy supply that, despite of novel findings in recent years, is poorly understood so far.

Authors with CRIS profile

Janina Müller-Deile
Mario Schiffer

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE)

How to cite

APA:

Müller-Deile, J., & Schiffer, M. (2014). The podocyte power-plant disaster and its contribution to glomerulopathy. Frontiers in Endocrinology, 5(DEC). https://doi.org/10.3389/fendo.2014.00209

MLA:

Müller-Deile, Janina, and Mario Schiffer. "The podocyte power-plant disaster and its contribution to glomerulopathy." Frontiers in Endocrinology 5.DEC (2014).

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