The tumor marker Fascin is strongly induced by the Tax oncoprotein of HTLV-1 through NF-κB signals

Kreß A, Kalmer M, Rowan AG, Grassmann R, Fleckenstein B (2011)

Publication Type: Journal article

Publication year: 2011

Journal

Blood American Society of Hematology

Book Volume: 117

Pages Range: 3609-3612

Journal Issue: 13

DOI: 10.1182/blood-2010-09-305805

Abstract

Oncogenic transformation of CD4+ T cells by human T-cell lymphotropic virus type 1 (HTLV-1) is understood as the initial step to adult T-cell leukemia/lymphoma, a process that is mainly initiated by perturbation of cellular signaling by the viral Tax oncoprotein, a potent transcriptional regulator. In search of novel biomarkers with relevance to oncogenesis, we identified the tumor marker and actin-bundling protein Fascin (FSCN1) to be specifically and strongly up-regulated in both HTLV-1 - transformed and adult T-cell leukemia/lymphoma patient-derived CD4+ T cells. Fascin is important for migration and metastasis in various types of cancer. Here we report that a direct link can exist between a single viral oncoprotein and Fascin expression, as the viral oncoprotein Tax was sufficient to induce high levels of Fascin. Nuclear factor-κB signals were important for Tax-mediated transcriptional regulation of Fascin in T cells. This suggests that Fascin up-regulation by Tax contributes to the development of HTLV-1 - associated pathogenesis. © 2011 by The American Society of Hematology.

Authors with CRIS profile

Andrea Thoma-Kreß Lehrstuhl für Klinische und Molekulare Virologie Bernhard Fleckenstein Medizinische Fakultät

Involved external institutions

Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB)

How to cite

APA:

Kreß, A., Kalmer, M., Rowan, A.G., Grassmann, R., & Fleckenstein, B. (2011). The tumor marker Fascin is strongly induced by the Tax oncoprotein of HTLV-1 through NF-κB signals. Blood, 117(13), 3609-3612. https://dx.doi.org/10.1182/blood-2010-09-305805

MLA:

Kreß, Andrea, et al. "The tumor marker Fascin is strongly induced by the Tax oncoprotein of HTLV-1 through NF-κB signals." Blood 117.13 (2011): 3609-3612.

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