Polymers in drug delivery-state of the art and future trends
Grund S, Bauer M, Fischer D (2011)
Publication Type: Journal article
Publication year: 2011
Journal
Book Volume: 13
Pages Range: B61-B87
Journal Issue: 3
Abstract
Advances in biotechnology, proteomics, and genomics, as well as the deeper understanding of the molecular and cellular bases of pathophysiological states, have allowed the development of novel drugs such as proteins, peptides, and nucleic acids as therapeutic strategies of the future. Their application, however, requires sophisticated drug delivery systems which can be used to alter the pharmacokinetics and release characteristics of drugs, and to increase tissue specificity and biocompatibility. In this context, polymers provide the most promising avenue in drug release control due to their favorable, adjustable characteristics, and possibilities for further modification. Advances in the biomedical sciences have had a significant impact on the design and development of new and intelligent drug delivery systems for more controlled and targeted drug application. This review summarizes the status quo of polymer use for drug delivery with a special focus on structure-property relationships and gives overviews of various polymers, the relevant parameters in drug delivery and the most promising trends in the future. Advances in biotechnology, proteomics and genomics, and the deeper understanding of the molecular and cellular bases of pathophysiological states, have allowed the development of novel drugs such as proteins, peptides, and nucleic acids as therapeutic strategies. Their application requires sophisticated delivery systems which can be used to alter the pharmacokinetics and release characteristics of drugs, and to increase tissue specificity and biocompatibility. This review summarizes the status quo of polymer use for drug delivery with a focus on structure-property relationships and gives overviews of various polymers, the relevant parameters in drug delivery and the most promising trends in the future. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Authors with CRIS profile
Involved external institutions
Germany (DE)How to cite
APA:
Grund, S., Bauer, M., & Fischer, D. (2011). Polymers in drug delivery-state of the art and future trends. Advanced Engineering Materials, 13(3), B61-B87. https://doi.org/10.1002/adem.201080088
MLA:
Grund, Stefan, Marius Bauer, and Dagmar Fischer. "Polymers in drug delivery-state of the art and future trends." Advanced Engineering Materials 13.3 (2011): B61-B87.
BibTeX: Download