Star-shaped block copolymers by copper-catalyzed azide-alkyne cycloaddition for potential drug delivery applications
Von Der Ehe C, Kempe K, Bauer M, Baumgaertel A, Hager MD, Fischer D, Schubert US (2012)
Publication Type: Journal article
Publication year: 2012
Journal
Book Volume: 213
Pages Range: 2146-2156
Journal Issue: 20
Abstract
Star-shaped poly(μ-caprolactone) is synthesized by ring-opening polymerization and subsequently functionalized with alkyne groups. These are utilized for the attachment of linear poly(ethylene glycol) monomethyl ether azide (mPEG-N 3) and poly(2-ethyl-2-oxazoline) azide (PEtOx-N 3) by copper-catalyzed azide-alkyne cycloaddition (CuAAC). The resulting amphiphilic star-shaped block copolymers are characterized by SEC, MALDI-TOF mass spectrometry, NMR spectroscopy, and DLS. In order to elucidate the potential of both systems as drug carriers their loading capacity is studied with a model system, the hydrophobic dye fat brown RR. Furthermore, erythrocyte aggregation tests provide first indications that the two different star-shaped block copolymers are compatible for potential applications in a biological context. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Germany (DE)How to cite
APA:
Von Der Ehe, C., Kempe, K., Bauer, M., Baumgaertel, A., Hager, M.D., Fischer, D., & Schubert, U.S. (2012). Star-shaped block copolymers by copper-catalyzed azide-alkyne cycloaddition for potential drug delivery applications. Macromolecular Chemistry and Physics, 213(20), 2146-2156. https://doi.org/10.1002/macp.201200307
MLA:
Von Der Ehe, Christian, et al. "Star-shaped block copolymers by copper-catalyzed azide-alkyne cycloaddition for potential drug delivery applications." Macromolecular Chemistry and Physics 213.20 (2012): 2146-2156.
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