Simulation of the long-term fate of superparamagnetic iron oxide-based nanoparticles using simulated biological fluids
Rabel M, Warncke P, Gruettner C, Bergemann C, Kurland HD, Mueller R, Dugandzic V, Thamm J, Mueller FA, Popp J, Cialla-May D, Fischer D (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 14
Pages Range: 1681-1706
Journal Issue: 13
Abstract
Aim: To simulate the stability and degradation of superparamagnetic iron oxide nanoparticles (MNP) in vitro as part of their life cycle using complex simulated biological fluids. Materials & methods: A set of 13 MNP with different polymeric or inorganic shell materials was synthesized and characterized regarding stability and degradation of core and shell in simulated biological fluids. Results: All MNP formulations showed excellent stability during storage and in simulated body fluid. In endosomal/lysosomal media the degradation behavior depended on shell characteristics (e.g., charge, acid-base character) and temperature enabling the development of an accelerated stress test protocol. Conclusion: Kinetics of transformations depending on the MNP type could be established to define structure-activity relationships as prediction model for rational particle design.
Authors with CRIS profile
Involved external institutions
Leibniz-Institut für Photonische Technologien e.V.
Germany (DE)
Friedrich-Schiller-Universität Jena
Germany (DE)
micromod Partikeltechnologie GmbH
Germany (DE)
chemicell GmbH
Germany (DE)
Germany (DE)
Friedrich-Schiller-Universität Jena
Germany (DE)
micromod Partikeltechnologie GmbH
Germany (DE)
chemicell GmbH
Germany (DE)
How to cite
APA:
Rabel, M., Warncke, P., Gruettner, C., Bergemann, C., Kurland, H.-D., Mueller, R.,... Fischer, D. (2019). Simulation of the long-term fate of superparamagnetic iron oxide-based nanoparticles using simulated biological fluids. Nanomedicine, 14(13), 1681-1706. https://doi.org/10.2217/nnm-2018-0382
MLA:
Rabel, Martin, et al. "Simulation of the long-term fate of superparamagnetic iron oxide-based nanoparticles using simulated biological fluids." Nanomedicine 14.13 (2019): 1681-1706.
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