Bioinspired titanium coatings: Self-assembly of collagen-alginate films for enhanced osseointegration
Gregurec D, Wang G, Pires RH, Kosutic M, Luedtke T, Delcea M, Enrique Moya S (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 4
Pages Range: 1978-1986
Journal Issue: 11
DOI: 10.1039/c6tb00204h
Abstract
Achieving long term osseointegration is fundamental to the development of successful bone implants. A key aspect for improving long term osseointegration on titania surfaces is to gain control of nano- and microscale features. The so called biological approach is applied here to modify the surface of titania by coating it with a self-assembled and chemically crosslinked biopolymer film made of alginate and collagen. The biofilm coated titania closely mimics the bone extracellular matrix in bio-morphology and mechanical properties. Biofilms are prepared using the layer by layer technique combined with carbodiimide chemistry to achieve a stable and compact structure. Alginate-collagen coatings display fibrillar morphology with an apparent fiber diameter of ∼50 nm and lengths ranging from a few hundred nanometers to ∼3 μm, mimicking therefore the extracellular matrix of the bone in fiber length and extent. Osteoblast MC3T3-E1 cells showed enhanced adhesion on the coated surface compared to the bare titania and a superior biological activity of the alginate-terminated coating that interfaces the cells in biological fluids.
Authors with CRIS profile
Involved external institutions
CIC biomaGUNE (Centro de Investigación Cooperativa en Biomateriales)
Spain (ES)
Universität Greifswald
Germany (DE)
Spain (ES)
Universität Greifswald
Germany (DE)
How to cite
APA:
Gregurec, D., Wang, G., Pires, R.H., Kosutic, M., Luedtke, T., Delcea, M., & Enrique Moya, S. (2016). Bioinspired titanium coatings: Self-assembly of collagen-alginate films for enhanced osseointegration. Journal of Materials Chemistry B, 4(11), 1978-1986. https://doi.org/10.1039/c6tb00204h
MLA:
Gregurec, Danijela, et al. "Bioinspired titanium coatings: Self-assembly of collagen-alginate films for enhanced osseointegration." Journal of Materials Chemistry B 4.11 (2016): 1978-1986.
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