Biocompatible superparamagnetic carriers of chondroitin sulfate
Rivera LMR, Paterno LG, Chaves NL, Gregurec D, Bao SN, Moya SE, Jain M, Azevedo RB, Morais PC, Soler MAG (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 6
Article Number: 066106
Journal Issue: 6
Abstract
The present study reports on the fabrication, morphological and structural characterizations, magnetic and biological tests of a biocompatible superparamagnetic carrier comprising iron oxide nanoparticle (ION) surface-functionalized with chondroitin sulfate (ChS), labelled ION@ChS. The reported ION@ChS sample is produced by alkaline coprecipitation of Fe2+ and Fe3+ ions in aqueous media in the presence of ChS. Fourier Transform infrared, Raman and x-ray photoelectron spectroscopies provide evidences for coordination of the ChS molecule (mainly through sulfonic groups) onto the ION's surface. Transmission electron microscopy reveals that the ION@ChS are nearly spherical (mean diameter = 8.2 nm ± 0.1) and almost monodispersed (diameter dispersity = 0.11 ± 0.01), while dynamic light scattering and electrophoretic mobility measurements confirm the presence of ChS at the ION's surface, providing mean hydrodynamic diameter (∼100 nm) and very high negative zeta potential (around -50 mV). Moreover, the ION@ChS is superparamagnetic at room temperature, with no coercivity or remanence. Cell viability tests performed by means of the MTT assay indicates that ION@ChS shows no cytotoxiciy effect (p < 0.05). Therefore, one can anticipate potential biotechnological applications of the ION@ChS sample for site-specific delivery of ChS as well as a contrast agent in magnetic resonance imaging.
Authors with CRIS profile
Involved external institutions
Universidade de Brasília
Brazil (BR)
CIC biomaGUNE (Centro de Investigación Cooperativa en Biomateriales)
Spain (ES)
University of Connecticut
United States (USA) (US)
Brazil (BR)
CIC biomaGUNE (Centro de Investigación Cooperativa en Biomateriales)
Spain (ES)
University of Connecticut
United States (USA) (US)
How to cite
APA:
Rivera, L.M.R., Paterno, L.G., Chaves, N.L., Gregurec, D., Bao, S.N., Moya, S.E.,... Soler, M.A.G. (2019). Biocompatible superparamagnetic carriers of chondroitin sulfate. Materials Research Express, 6(6). https://doi.org/10.1088/2053-1591/ab0950
MLA:
Rivera, Luis M. R., et al. "Biocompatible superparamagnetic carriers of chondroitin sulfate." Materials Research Express 6.6 (2019).
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