Transgene-free remote magnetothermal regulation of adrenal hormones

Rosenfeld D, Senko AW, Moon J, Yick I, Varnavides G, Gregurec D, Koehler F, Chiang PH, Christiansen MG, Maeng LY, Widge AS, Anikeeva P (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Science Advances American Association for the Advancement of Science

Book Volume: 6

Article Number: eaaz3734

Journal Issue: 15

DOI: 10.1126/sciadv.aaz3734

Abstract

The field of bioelectronic medicines seeks to modulate electrical signaling within peripheral organs, providing temporally precise control of physiological functions. This is usually accomplished with implantable devices, which are often unsuitable for interfacing with soft and highly vascularized organs. Here, we demonstrate an alternative strategy for modulating peripheral organ function, which relies on the endogenous expression of a heat-sensitive cation channel, transient receptor potential vanilloid family member 1 (TRPV1), and heat dissipation by magnetic nanoparticles (MNPs) in remotely applied alternating magnetic fields. We use this approach to wirelessly control adrenal hormone secretion in genetically intact rats. TRPV1-dependent calcium influx into the cells of adrenal cortex and medulla is sufficient to drive rapid release of corticosterone and (nor)epinephrine. As altered levels of these hormones have been correlated with mental conditions such as posttraumatic stress disorder and major depression, our approach may facilitate the investigation of physiological and psychological impacts of stress.

Authors with CRIS profile

Danijela Gregurec

Involved external institutions

Wellesley College US United States (USA) (US) Massachusetts Institute of Technology (MIT) US United States (USA) (US) Eidgenössische Technische Hochschule Zürich (ETHZ) / Swiss Federal Institute of Technology in Zurich CH Switzerland (CH) Harvard University US United States (USA) (US) CIC biomaGUNE (Centro de Investigación Cooperativa en Biomateriales) ES Spain (ES)

How to cite

APA:

Rosenfeld, D., Senko, A.W., Moon, J., Yick, I., Varnavides, G., Gregurec, D.,... Anikeeva, P. (2020). Transgene-free remote magnetothermal regulation of adrenal hormones. Science Advances, 6(15). https://doi.org/10.1126/sciadv.aaz3734

MLA:

Rosenfeld, Dekel, et al. "Transgene-free remote magnetothermal regulation of adrenal hormones." Science Advances 6.15 (2020).

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