Global brain dynamics embed the motor command sequence of Caenorhabditis elegans.

Kato S, Kaplan HS, Schrödel T, Skora S, Lindsay TH, Yemini E, Lockery S, Zimmer M (2015)

Publication Status: Published

Publication Type: Journal article

Publication year: 2015

Journal

Cell Elsevier

Book Volume: 163

Pages Range: 656-69

Journal Issue: 3

DOI: 10.1016/j.cell.2015.09.034

Abstract

While isolated motor actions can be correlated with activities of neuronal networks, an unresolved problem is how the brain assembles these activities into organized behaviors like action sequences. Using brain-wide calcium imaging in Caenorhabditis elegans, we show that a large proportion of neurons across the brain share information by engaging in coordinated, dynamical network activity. This brain state evolves on a cycle, each segment of which recruits the activities of different neuronal sub-populations and can be explicitly mapped, on a single trial basis, to the animals' major motor commands. This organization defines the assembly of motor commands into a string of run-and-turn action sequence cycles, including decisions between alternative behaviors. These dynamics serve as a robust scaffold for action selection in response to sensory input. This study shows that the coordination of neuronal activity patterns into global brain dynamics underlies the high-level organization of behavior.

Authors with CRIS profile

Tina Fraaß

Involved external institutions

Vienna Biocenter VBC AT Austria (AT) University of Oregon (UO) US United States (USA) (US) Columbia University US United States (USA) (US) Forschungsinstitut für Molekulare Pathologie / Research Institute of Molecular Pathology (IMP) AT Austria (AT)

How to cite

APA:

Kato, S., Kaplan, H.S., Schrödel, T., Skora, S., Lindsay, T.H., Yemini, E.,... Zimmer, M. (2015). Global brain dynamics embed the motor command sequence of Caenorhabditis elegans. Cell, 163(3), 656-69. https://dx.doi.org/10.1016/j.cell.2015.09.034

MLA:

Kato, Saul, et al. "Global brain dynamics embed the motor command sequence of Caenorhabditis elegans." Cell 163.3 (2015): 656-69.

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