Die Geschichte des ‚Freezing-of-gait‘ beim Parkinson-Syndrom – vom Phänomen zum Symptom

Klucken J, Winkler J, Krüger R, Jost W (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Fortschritte der Neurologie - Psychiatrie Georg Thieme Verlag

Book Volume: 88

Pages Range: 573-581

Journal Issue: 9

DOI: 10.1055/a-1227-6258

Abstract

The background of the freezing-of-gait (FOG) phenomenon in Parkinson's syndrome is presented in this review. The following issues are addressed: characterization of the symptom freezing and its subtypes that challenge standardized diagnostic procedures; available assessment methods generating freezing-related parameters that not only support clinical studies but can also be applied in everyday care, and current therapy options. FOG exists in different subtypes, and clinical and diagnostic definitions are limited by subjective characterization and semi-standardized tests. FOG-specific drug options are not existing, apart from the optimization of dopaminergic medication, which may also be due to the poor discriminatory power of standardized diagnostics. This is also true for deep brain stimulation. Both of these therapeutic options may be due not only to the complex neural network alterations as a motor-control correlate of FOG, but also because of challenging diagnostic assessments methodologies. Innovative, wearable, sensor-based diagnostic strategies are currently being developed, and supportive therapies using tools and technologies focusing on 'cueing' are becoming increasingly well accepted. Even though high level evidence is missing, they provide a helpful treatment option for individualized therapy. It can be assumed that these options will become particularly popular due to technological progress and likely alter the everyday treatment challenges faced by doctors and therapists.

Authors with CRIS profile

Jochen Klucken Department of Molecular Neurology Jürgen Winkler Professur für Molekulare Neurologie

Involved external institutions

University of Luxembourg LU Luxembourg (LU) Parkinson-Klinik Ortenau DE Germany (DE)

How to cite

APA:

Klucken, J., Winkler, J., Krüger, R., & Jost, W. (2020). Die Geschichte des ‚Freezing-of-gait‘ beim Parkinson-Syndrom – vom Phänomen zum Symptom. Fortschritte der Neurologie - Psychiatrie, 88(9), 573-581. https://doi.org/10.1055/a-1227-6258

MLA:

Klucken, Jochen, et al. "Die Geschichte des ‚Freezing-of-gait‘ beim Parkinson-Syndrom – vom Phänomen zum Symptom." Fortschritte der Neurologie - Psychiatrie 88.9 (2020): 573-581.

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